Results 111 to 120 of about 68,565 (138)

Programmable Motion of Optically Gated Electrically Powered Engineered Microswimmer Robots

Small, EarlyView.
A programmable microswimmer leveraging induced‐charge electrophoresis (ICEP) is presented for propulsion and optically modulated electrokinetic propulsion (OMEP) for steering. ZnO‐coated sections enable optical torque generation under uniform illumination, simplifying control.
Matan Zehavi, Ido Rachbuch, Sinwook Park, Touvia Miloh, Orlin D. Velev, Gilad Yossifon   +5 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Recent progress on nanotechnologies for enhancing blood‐brain barrier permeability

Smart Molecules, EarlyView.
In this review, we summarize innovative strategies for harnessing the power of nanotechnology to enhance blood‐brain barrier permeability, a key challenge for central nervous system (CNS) drug delivery. We overview structural innovation of nanocarriers, improvements in targeting strategies, and nanotechnology‐enhanced brain imaging.
Qibin Liu, Zhuoqian Chen, Anthony Guiseppi‐Elie, Fanling Meng, Liang Luo   +4 more
wiley   +1 more source

Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, EarlyView.
This paper reviews the preparation methods and materials of microneedles for drug delivery, summarizes the structures and types of microneedle systems, analyzes the influence of antigens and adjuvants on the efficacy of microneedle vaccines, and reviews the current application status of microneedles in the fields of vaccines and immunotherapy by ...
Haiyao Jia, Jinyuan Liu, Mengqian Shi, Manzar Abbas, Ruirui Xing, Xuehai Yan   +5 more
wiley   +1 more source

Biohybrid Microrobots Based on Jellyfish Stinging Capsules and Janus Particles for In Vitro Deep‐Tissue Drug Penetration

Small Science, EarlyView.
This study introduces a biohybrid microrobot utilizing jellyfish‐stinging capsules as nanoinjectors, integrated onto Janus particles. Controlled by magnetic and electric fields, these microrobots achieve deep tissue penetration and precise drug delivery.
Sinwook Park, Noga Barak, Tamar Lotan, Gilad Yossifon   +3 more
wiley   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules. [PDF]

, 2019
Cao, Yuhong, Cestellos-Blanco, Stefano, Doudna, Jennifer A, Ma, Enbo, Qiu, Ruoyi, Su, Yude, Yang, Peidong   +6 more
core  

Duodenal Laser Ablation for Treatment of Type 2 Diabetes: Results of First in Human Study

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Diabetes mellitus (DM) significantly impacts global health and economies. Despite various therapies, managing DM remains challenging. Bariatric surgery has shown efficacy in obese patients with type 2 diabetes mellitus (T2DM), but its utilization remains low.
Viktorie Kovarova, Ivana Lankova, Evzen Machytka, Katerina Knotkova, Helena Kratochvílová, Marek Beneš, Julius Spicak, Adam Vasura, Eran Goldin, Gavriel Munter, Tomas Zima, Milos Mraz, Hila Dagan, Brian Levy, Martin Haluzik, Jan Kral   +15 more
wiley   +1 more source