Results 101 to 110 of about 127,262 (303)

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

An Explorative Study on Calcium Electroporation for Low-risk Basal Cell Carcinoma

Acta Dermato-Venereologica
In electrochemotherapy, permeabilization of the cell membrane by electric pulses increases the anti-tumour effect of chemotherapeutics. In calcium electroporation, chemotherapy is replaced by calcium chloride with obvious benefits.
Stine R. Wiegell, Kristoffer Hendel, Christine S.K. Fuchs, Julie Gehl, Mille Vissing, Sara W. Bro, Jesper T. Troelsen, Gregor B.E. Jemec, Merete Haedersdal   +8 more
doaj   +1 more source

Conductivity in Jurkat cell suspension after ultrashort electric pulsing

, 2004
Ultrashort electric pulses applied to similar cell lines such as Jurkat and HL-60 cells can produce markedly different results , which have been documented extensively over the last few years.
Kolb, J, Joshi, R P, Garner, A L, Beebe, S, Chen, N, Swanson, R J, Chen, G, Schoenbach, K H   +7 more
core  

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Concurrently Achieving 4.6 W/M2 and 120,000 Cyclability Enabled by Extendable Swing Arms in Rotational Triboelectric Nanogenerator

Advanced Science, EarlyView.
A rotational energy harvesting device that successfully reconciles high power density with mechanical durability through a hybrid sliding‐and‐bouncing kinematic mechanism is reported. The success reported in our paper includes addressing a dilemma where enhanced electrical output comes at the cost of increased friction and wear, limiting the practical ...
Yihong Lin, Jiaming Zhou, In‐Yong Suh, Eunjong Kim, Kin Chiu Yip, Dae‐jin Kim, Jang‐Mook Jeong, Young‐Jun Kim, Jinyoung Jeon, Ju‐Hyuck Lee, Yoon‐Hwae Hwang, Sang‐Woo Kim, Dong‐Myeong Shin   +12 more
wiley   +1 more source

Stable transformation of sugar beet protoplasts by electroporation.

, 1989
Conditions were optimized for the culture, antibiotic selection and stable transformation by electroporation of suspension culture protoplasts of sugarbeet,Beta vulgaris L..
Jones, M.G.K., Jones, M. G. K., Lindsey, K.   +2 more
core  

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Versatile DNA‐Functionalized Biohybrid Hydrogel Platforms for Electrothermally Activated On‐Demand Payload Release

Advanced Science, EarlyView.
A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun, Zhenshuai Tang, Jia Zhang, Rui Song, Wei Luo, Juan Huang, Jincheng Zeng, Zhen He, Hao Zhang   +8 more
wiley   +1 more source

Enhancement effect of urea toward electroporation-mediated plasmid transfection efficiency in the HEK-293 cell line

Research in Pharmaceutical Sciences
Intracellular delivery is crucial in biological and medical studies. Although many molecular tools have been created for cell-based gene therapies, it remains challenging to introduce external molecules into cells.
Mahshid Mowla, Gilar Gorji-Bahri, Hamid Reza Moghimi, Atieh Hashemi   +3 more
doaj   +1 more source

Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles

Molecular Imaging, 2018
Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal
Govindarajan Srimathveeravalli PhD, Dalya Abdel-Atti BS, Carlos Pérez-Medina PhD, Haruyuki Takaki MD, PhD, Stephen B. Solomon MD, Willem J. M. Mulder PhD, Thomas Reiner PhD   +6 more
doaj   +1 more source