Results 51 to 60 of about 24,505 (227)

Early ophthalmic findings in joubert syndrome

Journal of the Egyptian Ophthalmological Society, 2017
Aim The aim of this study was to determine the early ophthalmic and electrophysiological features of Joubert syndrome (JS) in young Egyptian children and compare them with other studies.
Amira A Abdelazeem, Olfat A Hassanin, Amal A Elgohary, Maha S Zaki, Amany H Galal, Joseph G Gleeson   +5 more
doaj   +1 more source

Development of a novel knockout model of retinitis pigmentosa using Pde6b-knockout Long–Evans rats

Frontiers in Medicine, 2022
Although rats with melanin-pigmentated retinal pigment epithelial (RPE) cells are physiologically more appropriate models for human eye research than their albino counterparts, reliable models from the former strain are not available to study retinal ...
Jee Myung Yang, Jee Myung Yang, Bora Kim, Jiehoon Kwak, Min Kyung Lee, Jeong Hoon Kim, In-Jeoung Baek, In-Jeoung Baek, Young Hoon Sung, Young Hoon Sung, Joo Yong Lee   +10 more
doaj   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Evidence of the neuroprotective role of citicoline in glaucoma patients [PDF]

, 2008
The glaucomatous disease is currently considered a disease involving ocular and visual brain structures. This new approach to glaucoma introduces the possibility of inducing an improvement by means of a pharmacological approach similar to that used in ...
Armington, Bach, Birbamer, Boismare, Cacabelos, Campos, Celesia, Celesia, Chaturvedi, Colotto, Fiorentini, Garway-Heath, Goracci, Gottlob, Gottlob, Gottlob, Graham, Greenstein, Gupta, Gur, Holder, Horn, Kakihana, Kennedy, Klistorner, Leguire, Maffei, Martus, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Pecori-Giraldi, Porciatti, Porciatti, Rejdak, Salgarello, Secades, Serra, Vaegan, Ventura, Ventura, Virno, Watanabe, Weber, Weiss, Yucel, Yucel   +55 more
core   +1 more source

Identification and functional validation of a novel disease‐causing variant in the noncoding region of NYX

Acta Ophthalmologica, EarlyView.
Abstract Purpose Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders, with ~30% of cases remaining genetically unsolved. Complete congenital stationary night blindness (cCSNB) is a subtype of IRD, usually associated with reduced visual acuity, nystagmus and high myopia.
Filip Spanic, Christelle Michiels, Julien Navarro, Aline Antonio, Christel Condroyer, Camille Andrieu, Billy Gipsy, Sylvie Berthémy‐Pellet, Mathilde Gallice, Isabelle Audo, Christina Zeitz   +10 more
wiley   +1 more source

A spatially specified systems pharmacology therapy for axonal recovery after injury

Frontiers in Pharmacology, 2023
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that ...
Mustafa M. Siddiq, Nicholas P. Johnson, Nicholas P. Johnson, Nicholas P. Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A. Toro, Carlos A. Toro, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher P. Cardozo, Christopher P. Cardozo, Christopher P. Cardozo, Christopher L. Passaglia, Ravi Iyengar   +22 more
doaj   +1 more source

The Visual Mechanisms of Tenebrio Molitor: Changes in the Electro-Retinogram as Function of the Stimulus Duration [PDF]

, 1971
The ERG complex of the compound eye of the yellow mealworm bettle Tenebrimolitor (L.) separates into two components with stimulus durations of longer than 100 ms. These are the ‘on’ and the ‘off’ effects.
Yinon, U.
core  

The oscillatory response of the electroretinogram and neuronal adaptation

Acta Ophthalmologica, EarlyView.
Abstract After more than 50 years, there still remains a challenge and an interest to know more as well as extend and deepen our understanding of the small rapid wavelets, the oscillatory potentials (OPs), of the electroretinogram (ERG) and the neuronal adaptation of the retina.
Lillemor Wachtmeister, Anders Eklund
wiley   +1 more source

Detection of early age-related macular degeneration using novel functional parameters of the focal cone electroretinogram [PDF]

, 2014
The focal cone electroretinogram is a sensitive marker for macular disease, but have we unlocked its full potential? Typically assessment of waveform parameters is subjective and focuses on a small number of locations (e.g. the a-wave).
A Bird, A Fulton, A Vincent, AA Paupoo, AE Mentzer, Alison Mary Binns, AM Binns, Ashley Wood, B Falsini, B Falsini, B Lei, BJ Fowler, C Bunce, C Friedburg, C Gerth, C Westall, DC Hood, DC Hood, H Asi, H Nishihara, H Terasaki, J Ambati, J Bland, J Sunness, JA Hanley, JF Remulla, JK Chylack LT Wolfe, K Neelam, KE Mortlock, M Bach, M Gur, M Piccardi, M Sandberg, M Sandberg, ME Breton, N Peachey, N Wali, P Lachapelle, P Walter, R Granit, R Shiells, RA Bush, RE Hogg, Thomas Margrain, TY Wong, Y Miyake, Zsolt Ablonczy   +46 more
core   +3 more sources

Decline of Visual Function and Risk of Legal Blindness With Age in RPGR‐Associated Retinal Degeneration: A Multicenter Study

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This retrospective multicenter longitudinal analysis analysed the loss trajectory of best recorded visual acuity (BRVA) and Goldmann visual field (GVF) in RPGR‐associated retinal degeneration (RPGR‐RD). Methods Patients with genetically confirmed RPGR‐RD were classified into rod‐cone (RC), cone/cone‐rod (CR) and female‐carrier ...
Bela J. Parekh, Joshua D. Stein, Rebhi Abuzaitoun, Chris A. Andrews, Kari Branham, Dejan Milentijevic, Divya Narayanan, Naheed W. Khan, Suzann Pershing, Sophia Y. Wang, Baseer U. Ahmad, Thomas B. Connor, Jennifer L. Patnaik, Marc Mathias, Monique Leys, Brian McMillan, Nnana Amakiri, Taylor J. Johnson, Catherine Q. Sun, Jacque L. Duncan, K. Thiran Jayasundera, on behalf of the SOURCE consortium, Sejal Amin, Paul A. Edwards, Divya Srikumaran, Fasika Woreta, Jeffrey S. Schultz, Anurag Shrivastava, Baseer Ahmad, Louis R. Pasquale, Paul J. Bryar, Dustin D. French, Michelle Hribar, Merina Thomas, Brian L. Vanderbeek, Suzann Pershing, Sophia Y. Wang, Michael Deiner, Catherine Sun, Jennifer Patnaik, Prem Subramanian, Saleha Munir, Wuqaas Munir, Joshua Stein, Lindsey De Lott, Rajeev Ramachandran, Robert Feldman, Brian C. Stagg, Barbara Wirostko, Brian McMillian, Arsham Sheybani, Soshian Sarrapour, Kristen Harris‐Nwanyanwu   +52 more
wiley   +1 more source