Results 141 to 150 of about 293,062 (392)

Online investigation of lignin depolymerization via reactor-integrated electrospray ionization high-resolution mass spectrometry

Applications in Energy and Combustion Science, 2022
Depolymerization of lignin can yield phenolic monomeric platform molecules, but depolymerization and repolymerization are proposed as concurrent processes, which greatly limit the yield of monomeric products.
Cunhao Cui, Linyu Zhu, Jianfeng Ouyang, Yang Shen, Hairong Ren, Wenhao Yuan, Zhongyue Zhou, Fei Qi   +7 more
doaj  

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
wiley   +1 more source

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

Angewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim, Nicolás M. Morato, Prabir Saha, Pascal N. Eyimegwu, Aqeel A. Niyaz, Rui Huang, R. Graham Cooks, Ryan M. Phelan, Jared C. Lewis   +8 more
wiley   +2 more sources

Probing the nature of interactions in SH2 binding interfaces–evidence from electrospray ionization mass spectrometry [PDF]

, 1999
Evonne W. Chung, Denise Y. P. Henriques, Debora Renzoni, Craig J. Morton, Terrence D. Mulhern, Maureen Pitkeathly, John E. Ladbury, Carol V. Robinson   +7 more
openalex   +1 more source

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Advanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
wiley   +1 more source

Structural Insight Into a Human H Ferritin@Gold‐Monocarbene Adduct: Aurophilicity Revealed in a Biological Context

Angewandte Chemie, EarlyView.
Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini, Andrea Giachetti, Annalisa Guerri, Ane Martinez‐Castillo, Andrea Geri, Stefano Zineddu, Nicola G. A. Abrescia, Luigi Messori, Paola Turano, Antonio Rosato   +9 more
wiley   +2 more sources

Studies on metal-ion complex formation of crown ether derivatives incorporating a photoionizable spirobenzopyran moiety by electrospray ionization mass spectrometry [PDF]

, 2000
Keiichi Kimura, Hidefumi Sakamoto, Shinpei Kado, Ryuichi Arakawa, Masaaki Yokoyama   +4 more
openalex   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

Advanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma, Yihao Zhang, Junkai Cai, Baotong Ding, Yang Jiao, Chunying Duan   +5 more
wiley   +1 more source

Antiparallel β‐Sheet as a Key Motif of Amyloid‐β Inhibitor Designed via Topological Peptide Reprogramming

Angewandte Chemie, EarlyView.
Targeting Amyloid‐β (Aβ) aggregation requires a peptide‐based approach that accounts for the structural heterogeneity of Aβ. Here, we employ topological reprogramming via disulfide bonds to stabilize antiparallel β‐sheets within the dimeric peptide.
Dongjoon Im, Ye Eun Lee, Gyusub Yoon, William A. Goddard III, Tae Su Choi, Hugh I. Kim   +5 more
wiley   +2 more sources

High-Performance Liquid Chromatography--Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba) [PDF]

, 2000
Xiaoxiao He, Matthew W. Bernart, G. S. Nolan, Lin Liu, Michael Lindenmaier   +4 more
openalex   +1 more source