Results 71 to 80 of about 195,406 (308)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Characterization of lead-phytochelatin complexes by nano-electrospray ionization mass spectrometry

Frontiers in Microbiology, 2012
The role of phytochelatins (PCn, metal-binding oligopeptides with the general structure (γGlu - Cys)n - Gly (n = 2- 11)) in metal detoxification is assumed to be based on immobilization of metals, which prevents binding of metals to important ...
Christian eScheidegger, Christian eScheidegger, Marc J--F. Suter, Marc J--F. Suter, Renata eBehra, Laura eSigg, Laura eSigg   +6 more
doaj   +1 more source

Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules [PDF]

, 2017
G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a triethylamine ...
Scalabrin, Matteo, Palumbo, Manlio, Richter, Sara N.   +2 more
core   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj   +1 more source

An in silico MS/MS library for automatic annotation of novel FAHFA lipids. [PDF]

, 2015
BackgroundA new lipid class named 'fatty acid esters of hydroxyl fatty acids' (FAHFA) was recently discovered in mammalian adipose tissue and in blood plasma and some FAHFAs were found to be associated with type 2 diabetes.
Fahrmann, Johannes F, Fiehn, Oliver, Gennity, Ingrid, Kind, Tobias, Ma, Yan, Vaniya, Arpana   +5 more
core   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

An Organic Chemist’s Guide to Electrospray Mass Spectrometric Structure Elucidation

Molecules, 2019
Tandem mass spectrometry is an important tool for structure elucidation of natural and synthetic organic products. Fragmentation of odd electron ions (OE+) generated by electron ionization (EI) was extensively studied in the last few decades, however ...
Arnold Steckel, Gitta Schlosser
doaj   +1 more source

Analysis of Narrow-Leaf Lupin Proteins in Lupin-Enriched Pasta by Untargeted and Targeted Mass Spectrometry

Foods, 2020
The supplementation of different food items with grain legumes and, in particular, with lupin has been demonstrated to provide useful health benefits, especially in the area of cardiovascular disease prevention.
Gilda Aiello, Yuchen Li, Giovanna Boschin, Marco Stanziale, Carmen Lammi, Anna Arnoldi   +5 more
doaj   +1 more source

Electronic Spectroscopy of Isolated DNA Polyanions [PDF]

, 2018
In solution, UV-vis spectroscopy is often used to investigate structural changes in biomolecules (i.e., nucleic acids), owing to changes in the environment of their chromophores (i.e., the nucleobases).
Daly, Steven, Gabelica, Valérie, Porrini, Massimiliano, Rosu, Frederic   +3 more
core   +3 more sources