Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples
Cardiolipin is a prominent component of the mitochondrial inner membranes contributing to the regulation of multiple discrete mitochondrial functions. Here, we extend shotgun lipidomics to identify and quantitate cardiolipin molecular species directly ...
Xianlin Han+4 more
doaj
Characterization of lead-phytochelatin complexes by nano-electrospray ionization mass spectrometry
The role of phytochelatins (PCn, metal-binding oligopeptides with the general structure (γGlu - Cys)n - Gly (n = 2- 11)) in metal detoxification is assumed to be based on immobilization of metals, which prevents binding of metals to important ...
Christian eScheidegger+6 more
doaj +1 more source
Model mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids [PDF]
The aim of the study is to reveal molecular mechanisms of possible activity modulation of antimicrobial bis-quaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the ...
Gömöry, Ágnes+3 more
core +2 more sources
Suppression of collision-induced dissociation in a supersonically expanding gas [PDF]
In high-resolution mass spectrometry, an electrospray ionization source is often paired with an ion-funnel to enhance ion transmission. Although it is established that ions experience collision-induced dissociation as they pass through this device, the impact of gas-flow dynamics on ion fragmentation remains unexplored.
arxiv +1 more source
O -Acetylated sugars in the gas phase: stability, migration, positional isomers and conformation [PDF]
O-acetylations are functional modifications which can be found on different hydroxyl groups of glycans and which contribute to the fine tuning of their biological activity. Localizing the acetyl modifications is notoriously challenging in glycoanalysis, in particular because of their mobility: loss or migration of the acetyl group may occur through the
arxiv +1 more source
High throughput analysis is increasingly relevant in both industry and academia, with applications reaching from enzymology and drug discovery to organic reaction optimization and diagnostics.
Nicolás M. Morato, R. Graham Cooks
doaj
Analysis of Methoxymethylbenzoguanamine Resins Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Electrospray Ionization Mass Spectrometry [PDF]
Methoxymethylbenzoguanamine resins were analyzed by matrix-assisted laser desorption/ionization timeof-flight mass spectrometry (MALDI-TOF-MS) and electrospray ionization mass spectrometry (ESI-MS).
Arakawa Ryuichi+13 more
core +2 more sources
We investigated the fragmentation of the eudesmanolide-type sesquiterpene lactones 1α-(4-hydroxymethacryloyloxy)-3α,4α-epoxy-8α-hydroxyeudesm-11(13)-6α,12-olide (1) and 1α-(2,3-epoxyangeloyloxy)-4α,15-epoxy-8α-hydroxyeudesm-11(13)-6α,12-olide (2) by ...
Herbert Júnior Dias+4 more
doaj +1 more source
A Handy Ionized Spray Source Using a Cosmetic Ionizer for ESI Mass Spectrometry [PDF]
A handy electrospray ion source that made use of commercially available spray device for cosmetic foundation was designed and manufactured. The performance of the handy ion-source for electrospray ionization mass spectrometry (ESI-MS) was evaluated with ...
Arakawa Ryuichi+7 more
core +1 more source
Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction [PDF]
In this paper a method for the simultaneous quantification of the anti-fungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction is ...
Schiel, Xaver+2 more
core +1 more source