Results 101 to 110 of about 1,253 (161)

The evolutionary impact of childhood cancer on the human gene pool

Nature Communications
Germline pathogenic variants associated with increased childhood mortality must be subject to natural selection. Here, we analyze publicly available germline genetic metadata from 4,574 children with cancer [11 studies; 1,083 whole exome sequences (WES),
Ulrik Kristoffer Stoltze, Jon Foss-Skiftesvik, Thomas van Overeem Hansen, Simon Rasmussen, Konrad J. Karczewski, Karin A. W. Wadt, Kjeld Schmiegelow   +6 more
doaj   +1 more source

Purified Elongator shows Hrr25-dependendent phosphorylation that requires Ser-1198 and Ser-1202.

, 2015
(A) Elongator was purified using TAP-tagged Elp3 from either a HRR25 wild-type or a hrr25-I82G analog-sensitive mutant strain and supplemented with [γ-32P]ATP to examine endogenous Elp1 phosphorylation in the presence of DMSO (drug vehicle), 1NM-PP1 or ...
Wael Abdel-Fattah (682306), Alexander Hammermeister (682310), Daniel Jablonowski (682307), Mark Helm (11058), Rachael Di Santo (682308), Sara ten Have (383814), Raffael Schaffrath (383816), Michael J. R. Stark (383815), Viktor Scheidt (383813), Kathrin L. Thüring (682309)   +9 more
core   +1 more source

Elongator complex is required for long-term olfactory memory formation in Drosophila

, 2018
The evolutionarily conserved Elongator Complex associates with RNA polymerase II for transcriptional elongation. Elp3 is the catalytic subunit, contains histone acetyltransferase activity, and is associated with neurodegeneration in humans.
Dinghui Yu, Molee Chakraborty, Ronald L. Davis, Ying Tan, Seth Tomchik   +4 more
core   +1 more source

The Alteration of Proteomic Profiles in Hippocampus of Type 2 Diabetic Mice Associated With Cognitive Impairment

Bioinformatics and Biology Insights
Clinical and experimental studies have demonstrated that type 2 diabetes mellitus (T2DM) affects the brain structure and function, in particular the hippocampus, leading to cognitive impairments.
Yoottana Janthakhin, Sirikran Juntapremjit, Karin Hummel, Ebrahim Razzazi-Fazeli, Sutin Kingtong   +4 more
doaj   +1 more source

Abstract 2659: A thermally targeted carrier of p50 NLS peptide inhibits cancer cell proliferation by preventing NFκB nuclear translocation

, 2010
The application of rationally designed therapeutic peptides may improve outcomes in cancer treatment. These peptides hold the potential to directly target proliferative pathways and to inhibit their over-expression.
Drazen Raucher, Emily H. Thomas
core   +1 more source

Inhibition of Glioma Cell Proliferation by CPP-ELP-H1 Polypeptides in vitro.

, 2013
C6 cells were exposed to various concentrations of Bac-ELP1-H1 (A) or SynB1-ELP1-H1 (B) at 37°C or 42°C for 1 h, and cell number was determined 72 h later. C.
Gene L. Bidwell III (277232), Majid Khan (277235), Eddie Perkins (277233), Drazen Raucher (277237), Joshua Hughes (277234), Judy R. James (277236)   +5 more
core   +1 more source

Peripheral neuron phenotypes of familial dysautonomia are rescued by AAV-mediated gene therapy. [PDF]

Clin Auton Res
Wu HF, Saini T, Art J, Delaney W, Lefcort F, Zeltner N.   +5 more
europepmc   +1 more source

Exon-targeted U1 snRNA rescues splicing defects and ameliorates inherited optic neuropathy: A novel RNA-based treatment. [PDF]

Mol Ther Nucleic Acids
Zhang H, Sun X, Chen Z, Li Y, Chen W.
europepmc   +1 more source

Triple metachronous primary brain tumors: sequential occurrence of astrocytoma, atypical meningioma, and high-grade glioma without radiotherapy exposure. Illustrative case. [PDF]

J Neurosurg Case Lessons
Wang F, Chang M, Yan M, Qiu Y, Wang M, You W, Zhang J, Wang Z.   +7 more
europepmc   +1 more source

Autophosphorylation of conserved yeast and human casein kinase 1 isozymes regulates Elongator-dependent tRNA modifications. [PDF]

Nucleic Acids Res
Landrock MF, Krutyhołowa R, Böhnert P, Mazur J, Honc M, Hammermeister A, Bessler L, Scherf D, Elms A, Radczuk N, Skupien-Rabian B, Jankowska U, Herberg FW, Helm M, Klassen R, Glatt S, Schaffrath R.   +16 more
europepmc   +1 more source