Results 51 to 60 of about 1,253 (161)

Phosphorylation site mutations in Elp1 lead to changes in Kti12 association with Elongator.

, 2015
(A) elp1Δ ELP2-myc3 KTI12-HA6 yeast strains were transformed with either empty vector or plasmids expressing the indicated HA6-tagged ELP1 alleles (Table S2).
Wael Abdel-Fattah (682306), Alexander Hammermeister (682310), Daniel Jablonowski (682307), Mark Helm (11058), Rachael Di Santo (682308), Sara ten Have (383814), Raffael Schaffrath (383816), Michael J. R. Stark (383815), Viktor Scheidt (383813), Kathrin L. Thüring (682309)   +9 more
core   +1 more source

A neuron autonomous role for the familial dysautonomia geneELP1in sympathetic and sensory target tissue innervation [PDF]

Development, 2014
Familial dysautonomia (FD) is characterized by severe and progressive sympathetic and sensory neuron loss caused by a highly conserved germline point mutation of the human ELP1/IKBKAP gene. Elp1 is a subunit of the hetero-hexameric transcriptional elongator complex, but how it functions in disease-vulnerable neurons is unknown.
Marisa Z, Jackson, Katherine A, Gruner, Charles, Qin, Warren G, Tourtellotte   +3 more
openaire   +2 more sources

An Orthogonal Way of Writing the Tubulin Code

Cytoskeleton, Volume 83, Issue 5, Page 221-223, May 2026.
ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero, Emmanuel Derivery   +1 more
wiley   +1 more source

Spatial ecology and habitat selection of translocated European bison in the Romanian Carpathians

Ecosphere, Volume 17, Issue 4, April 2026.
Abstract Large herbivores play a critical role in maintaining ecosystem structure and function, yet their decline has disrupted ecological processes across much of the world. Species reintroductions aim to restore these dynamics, but how animals adapt to novel environments remains a key knowledge gap. European bison (Bison bonasus) are keystone species
L. C. V. Holland, R. Iosif, A. Aldea, C. Șerban, V. D. Popescu   +4 more
wiley   +1 more source

Elongator assembly is unaffected by a range of phosphorylation site mutations in Elp1.

, 2015
elp1Δ yeast strains expressing myc-tagged ELP2 and either HA-tagged ELP3 (A) or ELP5 (B) were transformed with either empty vector or plasmids expressing the indicated ELP1 alleles (Table S2).
Wael Abdel-Fattah (682306), Alexander Hammermeister (682310), Daniel Jablonowski (682307), Mark Helm (11058), Rachael Di Santo (682308), Sara ten Have (383814), Raffael Schaffrath (383816), Michael J. R. Stark (383815), Viktor Scheidt (383813), Kathrin L. Thüring (682309)   +9 more
core   +1 more source

Development of a Screening Platform to Identify Small Molecules That Modify ELP1 Pre-mRNA Splicing in Familial Dysautonomia [PDF]

SLAS Discovery, 2019
Familial dysautonomia (FD) is an autonomic and sensory neuropathy caused by a mutation in the splice donor site of intron 20 of the ELP1 gene. Variable skipping of exon 20 leads to a tissue-specific reduction in the level of ELP1 protein. We have shown that the plant cytokinin kinetin is able to increase cellular ELP1 protein levels in vivo and in ...
Monica, Salani, Fabio, Urbina, Anthony, Brenner, Elisabetta, Morini, Ranjit, Shetty, C Scott, Gallagher, Emily A, Law, Sara, Sunshine, Dylan J, Finneran, Graham, Johnson, Lisa, Minor, Susan A, Slaugenhaupt   +11 more
openaire   +2 more sources

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

Phosphorylation site mutations in Elp1 lead to changes in Hrr25 association with Elongator.

, 2015
elp1Δ ELP2-myc3 KTI12-HA6 yeast strains were transformed with either empty vector or plasmids expressing the indicated HA6-tagged ELP1 alleles (Table S2).
Wael Abdel-Fattah (682306), Alexander Hammermeister (682310), Daniel Jablonowski (682307), Mark Helm (11058), Rachael Di Santo (682308), Sara ten Have (383814), Raffael Schaffrath (383816), Michael J. R. Stark (383815), Viktor Scheidt (383813), Kathrin L. Thüring (682309)   +9 more
core   +1 more source

Loss of anticodon wobble uridine modifications affects tRNA(Lys) function and protein levels in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2015
In eukaryotes, wobble uridines in the anticodons of tRNA(Lys)UUU, tRNA(Glu)UUC and tRNA(Gln)UUG are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U).
Roland Klassen, Pia Grunewald, Kathrin L Thüring, Christian Eichler, Mark Helm, Raffael Schaffrath   +5 more
doaj   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source