Results 121 to 130 of about 27,445 (234)

Müller glia-mediated protection of retinal ganglion cells from ethambutol-induced neurotoxicity through brain-derived neurotrophic factor

Cell Communication and Signaling
Background Ethambutol (EMB)-associated optic neuropathy is the most common toxic optic neuropathy and poses a significant visual threat worldwide. This study aimed to investigate the neuroprotective roles of Müller glia, the most abundant macroglia in ...
Hui-Chen Cheng, Yu-Hui Wong, An-Guor Wang, Shih-Wei Chen, Yong-Lin Yang, Hsien-Chia Juan, Roxanne Hsiang-Chi Liou, Jenn-Yah Yu   +7 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Rothe Time Discretization and Weak Solutions for a Cutoff Westervelt System

Numerical Methods for Partial Differential Equations, Volume 42, Issue 5, September 2026.
ABSTRACTWe study a fully implicit Rothe time discretization for a cutoff first‐order formulation of the Westervelt equation. The key ingredients are the enthalpy variable and the primitive mobility variable, which turn each nonlinear time step into a uniformly monotone elliptic problem and avoid higher‐order energy estimates and inverse inequalities ...
Marvin Fritz
wiley   +1 more source

A Large Language Model‐Based Approach for Fault Detection and Its Application

Safety Science and Technology, Volume 1, Issue 3, September 2026.
This work proposes an interpretable fault detection framework utilizing pre‐trained large language models to overcome small sample sizes and label scarcity in industrial datasets. A stepwise tuple‐based validation mitigates hallucinations, ensuring reliable detection.
Yihua Ye, Yin Zhu, Liming Che, Hua Zhou
wiley   +1 more source

The Effect of Multi‐Strain Probiotics, Zinc and Copper on the Performance of Broiler Chickens Challenged With Clostridium perfringens

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Our study showed that challenging broiler chickens with Clostridium perfringens reduced performance and increased mortality. Conversely, supplementing the diet with additives, such as chelated zinc, chelated copper and probiotics, helped mitigate the negative effects of C. perfringens.
Amin Kazemi, Hassan Kermanshahi, Reza Majidzahe Heravi, Gholamreza Salehi Jouzani, Ali Javadmanesh   +4 more
wiley   +1 more source

Exploring sources of uncertainty in the estimate of waterfowl harvest in the United Kingdom

Wildlife Biology, Volume 2026, Issue 5, September 2026.
There is an urgent need to gather data on harvest rates of waterbirds in Europe to assess the sustainability of hunting. Estimates of total waterbird harvest in the United Kingdom (UK) and the relative harvest of different huntable species come from two separate surveys, the Value of Shooting (PACEC 2014) and National Gamebag Census (NGC), and these ...
Matthew B. Ellis, Hannah M. Lewis, Tom C. Cameron   +2 more
wiley   +1 more source

Automated Alignment of Math Items to Content Standards in Large‐Scale Assessments Using Language Models

Educational Measurement: Issues and Practice, Volume 45, Issue 3, Fall 2026.
Abstract Accurate alignment of items to content standards is critical for valid score interpretation in large‐scale assessments. This study evaluates three automated paradigms for aligning Math items with four domain labels and nineteen skill labels.
Qingshu Xu, Hong Jiao, Tianyi Zhou, Ming Li, Nan Zhang, Sydney Peters, Yanbin Fu   +6 more
wiley   +1 more source

Efficacy, Safety, and Pharmacokinetics of Upadacitinib Among Patients in East Asia With Moderately to Severely Active Ulcerative Colitis: A Post Hoc Subanalysis of Randomized Phase 3 Studies

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2709-2720, September 2026.
ABSTRACT Background and Aim Upadacitinib, a selective Janus kinase 1 inhibitor, is approved to treat moderately to severely active ulcerative colitis (UC). This post hoc subanalysis evaluated the efficacy, safety, and pharmacokinetics of upadacitinib in patients in East Asia. Methods U‐ACHIEVE (UC1; NCT02819635) and U‐ACCOMPLISH (UC2; NCT03653026) were
Shu Chen Wei, Hiroshi Nakase, Byong Duk Ye, Kang Chao, Hsin‐Yun Wu, Jason Eccleston, Xuan Yao, Hannah Palac, Mohamed‐Eslam F. Mohamed, Ana Victoria Ponce‐Bobadilla, Smitha Suravaram, Elena Marced Barrachina, Tadakazu Hisamatsu, Xiang Gao   +13 more
wiley   +1 more source

Evidence for a trade‐off between growth rate and xylem embolism resistance in 22 Eucalyptus species

New Phytologist, Volume 251, Issue 5, Page 2407-2426, September 2026.
Examples of cross‐sectional images of branchlets at 4× and 40×. Summary Within the growth–survival trade‐off framework, embolism resistance is considered a contributor to survival, yet whether greater embolism resistance inherently limits growth remains unclear.
Tiantian Pan, Vinod Jacob, Travis G. Britton, Julian Schrader, Jennifer M. R. Peters, Jinlong Li, Chongzhe Zhang, Jiahao Wen, Brendan Choat, Ian J. Wright   +9 more
wiley   +1 more source

Abatacept for steroid-refractory fulminant immune checkpoint inhibitor myocarditis with triple M overlap syndrome: a case report with serial endomyocardial biopsy assessment. [PDF]

Eur Heart J Case Rep
Matsui R, Sato K, Tajiri K, Ishizu T.
europepmc   +1 more source