Results 131 to 140 of about 206,297 (286)
Advanced Science, EarlyView.Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui +6 more
wiley +1 more source
Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss
Advanced Science, EarlyView.In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang +20 more
wiley +1 more source
The effect of leukaemia inhibitory factor (LIF) on bovine embryo development in vitro : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Animal Science at Massey University [PDF]
, 1995 The aim of the study was to investigate the effect of Leukaemia Inhibitory Factor (LIF) either during in vitro maturation (IVM) or in vitro culture (IVC) on bovine embryo development. Three main experiments were conducted using oocytes aspirated from 2-8
Margawati, Endang Tri
core
Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity
Advanced Science, EarlyView.The current bottleneck in metanephric mesenchyme (MM)‐derived nephron organoid development is the absence of a connected network of collecting ducts (CD) derived from the ureteric bud (UB). To address this limitation, this study proposes a hypoxia‐based differentiation method that mimics the natural renal developmental environment, enabling the ...
Hyeonji Lim +6 more
wiley +1 more source
Immunocytochemistry in Early Mammalian Embryos
, 2012 The preimplantation period of mammalian development hosts very important cellular and molecular events. This period starts with the fertilization of oocyte by sperm, a process that reprograms the highly differentiated nuclei of these germ cells, and leads to the generation of a totipotent one-cell embryo.
openaire +4 more sources
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, EarlyView.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
S22 Micromanipulation of mammalian embryos
The Journal of Toxicological Sciences, 1988 Micromanipulation of embryos provide a new and valuable biological tool for animal agriculture and medical fields. Current techniques for embryo manipulation are in practice but some of techniques is still way off for application. The present status in new biotechnology appling to animal science and medicine is reviewed and its future is also discussed.
openaire +3 more sources
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
Advanced Science, EarlyView.The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li +17 more
wiley +1 more source
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source