Results 11 to 20 of about 99,433 (149)

Human embryos cultured in vitro to 14 days [PDF]

Open Biology, 2017
We know a great deal about the development of the mammalian embryo until the time that the blastocyst implants into the uterus. With model organisms such as the mouse, we have also developed a considerable understanding of development immediately around ...
Samantha A. Morris
doaj   +1 more source

Post-Translational Modifications in Oocyte Maturation and Embryo Development

Frontiers in Cell and Developmental Biology, 2021
Mammalian oocyte maturation and embryo development are unique biological processes regulated by various modifications. Since de novo mRNA transcription is absent during oocyte meiosis, protein-level regulation, especially post-translational modification (
Yu Wu, Yu Wu, Mo Li, Mo Li, Mo Yang
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Application of a Microfluidic Chip with Mechanical Stimuli for Culturing Mouse Embryos in vitro [PDF]

International Journal Bioautomation, 2018
In order to solve some problems of lower blastocyst rate of early embryos in vitro and poor quality of blastocyst, application of a microfluidic chip with mechanical stimuli (MS) to imitate microenvironment of fallopian tube, to investigate the effect of
Jingchun Li, Qi Li, Guosheng Wei, Shengjun Liu, Jiabao Zhang, Yanbing Li   +5 more
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Developmental potential of aneuploid human embryos cultured beyond implantation

Nature Communications, 2020
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz   +11 more
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Biophysical models of early mammalian embryogenesis

Stem Cell Reports, 2023
Summary: Embryo development is a critical and fascinating stage in the life cycle of many organisms. Despite decades of research, the earliest stages of mammalian embryogenesis are still poorly understood, caused by a scarcity of high-resolution spatial ...
Alaina Cockerell, Liam Wright, Anish Dattani, Ge Guo, Austin Smith, Krasimira Tsaneva-Atanasova, David M. Richards   +6 more
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Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

Nature Communications, 2017
The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases:
Meng Zhu, Chuen Yan Leung, Marta N. Shahbazi, Magdalena Zernicka-Goetz   +3 more
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Oocyte specific lncRNA variant Rose influences oocyte and embryo development

Non-coding RNA Research, 2021
Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain either transcriptional noise or important ...
Rajan Iyyappan, Daria Aleshkina, Linkai Zhu, Zongliang Jiang, Veronika Kinterova, Andrej Susor   +5 more
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Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Nature Communications, 2019
How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling ...
Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz   +5 more
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Editing DNA Methylation in Mammalian Embryos [PDF]

International Journal of Molecular Sciences, 2020
DNA methylation in mammals is essential for numerous biological functions, such as ensuring chromosomal stability, genomic imprinting, and X-chromosome inactivation through transcriptional regulation. Gene knockout of DNA methyltransferases and demethylation enzymes has made significant contributions to analyzing the functions of DNA methylation in ...
Taiga Yamazaki, Yu Hatano, Ryoya Taniguchi, Noritada Kobayashi, Kazuo Yamagata   +4 more
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Insights into epigenetic patterns in mammalian early embryos

Protein & Cell, 2020
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a
Ruimin Xu, Chong Li, Xiaoyu Liu, Shaorong Gao   +3 more
doaj   +1 more source