Results 11 to 20 of about 209,877 (288)

Transgene-free mouse embryo models from chemical reprogramming reach early organogenesis [PDF]

Cell Regeneration
Embryo models derived from pluripotent stem cells (PSCs) have become powerful tools for dissecting mammalian embryonic development and advancing regenerative medicine.
Xiu Yu, Jichang Wang
doaj   +2 more sources

Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification [PDF]

eLife
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry-breaking event is executed through polarization of cells at the 8 cell stage and subsequent asymmetric divisions,
Adiyant Lamba, Meng Zhu, Maciej Meglicki, Sylwia Czukiewska, Lakshmi Balasubramaniam, Ron Hadas, Nina Weishaupt, Ekta M Patel, Yu Hua Kavanagh, Ran Wang, Naihe Jing, Magdalena Zernicka-Goetz   +11 more
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Cell arrest and cell death in mammalian preimplantation development [PDF]

, 2011
The causes, modes, biological role and prospective significance of cell death in preimplantation development in humans and other mammals are still poorly understood.
A Bettegowda, A Bettegowda, A Bettegowda, A Jurisicova, AE Crosier, AS Jakobsen, C Robert, C Wrenzycki, D Fabian, DH Betts, E Memili, E Vanneste, Eckhard Wolf, Felix A. Habermann, FF Paula-Lopes, FJ Pomar, Fred Sinowatz, G Kroemer, GE Exley, GS Salvesen, H Badr, HM Knijn, Horst-Dieter Reichenbach, I Robertson, J Fujita, J Laurincik, J Wang, J Yuan, JE Dietrich, JO Gjorret, JO Gjorret, Joerg Gromoll, K Goossens, K Hardy, L Dubrez-Daloz, L Galluzzi, L Leibfried, L Vandaele, LA Pradelli, M Boelhauve, M Lamkanfi, Marc Boelhauve, ME Guicciardi, MG Diskin, Myriam Reichenbach, P Chomczynski, P Lonergan, PS Malhi, R Draker, R Sartori, S Bilodeau-Goeseels, S Cory, SA Bustin, Sandra Leidenfrost, TA Brevini, TJ Fan, Tuna Güngör, Y Gavrieli   +57 more
core   +17 more sources

An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
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A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Nature Communications, 2021
Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz   +18 more
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Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

Stain-free detection of embryo polarization using deep learning

Scientific Reports, 2022
Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential of human embryos.
Cheng Shen, Adiyant Lamba, Meng Zhu, Ray Zhang, Magdalena Zernicka-Goetz, Changhuei Yang   +5 more
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IVEN: A quantitative tool to describe 3D cell position and neighbourhood reveals architectural changes in FGF4-treated preimplantation embryos.

PLoS Biology, 2021
Architectural changes at the cellular and organism level are integral and necessary to successful development and growth. During mammalian preimplantation development, cells reduce in size and the architecture of the embryo changes significantly.
Jessica E Forsyth, Ali H Al-Anbaki, Roberto de la Fuente, Nikkinder Modare, Diego Perez-Cortes, Isabel Rivera, Rowena Seaton Kelly, Simon Cotter, Berenika Plusa   +8 more
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Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
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Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β

Frontiers in Immunology, 2022
Mammalian blastocyst hatching is an essential prerequisite for successful embryo implantation. As the rate-limiting step of current assisted reproductive technology, understanding the key factors regulating blastocyst hatching would be significantly ...
Guangping Yang, Jianhua Chen, Yanni He, Hui Luo, Hongxia Yuan, Liangliang Chen, Lingli Huang, Fei Mao, Saifei Hu, Yun Qian, Congxiu Miao, Ruizhi Feng, Ruizhi Feng   +12 more
doaj   +1 more source