Biosynthesis and expression of zona pellucida glycoproteins in mammals [PDF]
, 2001 The zona pellucida (ZP) is an extracellular matrix surrounding the oocyte and the early embryo that exerts several important functions during fertilization and early embryonic development.
Kölle, S. +2 more
core +1 more source
Building an apical domain in the early mouse embryo: lessons, challenges and perspectives [PDF]
, 2019 Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well-understood. Recent studies suggest that unique
Zernicka-Goetz, Magdalena, Zhu, Meng
core +1 more source
Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo [PDF]
, 2011 Mammalian embryogenesis is a dynamic process involving gene expression and mechanical forces between proliferating cells. The exact nature of these interactions, which determine the lineage patterning of the trophectoderm and endoderm tissues occurring ...
A Jedrusik +36 more
core +4 more sources
Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
Nature Communications, 2017 The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases:
Meng Zhu +3 more
doaj +1 more source
A robust system for RNA interference in the chicken using a modified microRNA operon [PDF]
, 2006 RNA interference (RNAi) provides an effective method to silence gene expression and investigate gene function. However, RNAi tools for the chicken embryo have largely been adapted from vectors designed for mammalian cells.
Boardman +53 more
core +1 more source
Formation of embryos of the Earth and the Moon from the common rarefied condensation and their subsequent growth [PDF]
Solar System Research, 2018, v. 52, N 5, p. 401-416, 2020 Embryos of the Moon and the Earth may have formed as a result of contraction of a common parental rarefied condensation. The required angular momentum of this condensation could largely be acquired in a collision of two rarefied condensations producing the parental condensation. With the subsequent growth of embryos of the Moon and the Earth taken into
arxiv +1 more source
Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
Nature Communications, 2019 How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling ...
Neophytos Christodoulou +5 more
doaj +1 more source
Insights into epigenetic patterns in mammalian early embryos
Protein & Cell, 2020 Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a
Ruimin Xu +3 more
doaj +1 more source
Molecular recording of mammalian embryogenesis. [PDF]
, 2019 Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt +13 more
core +2 more sources
Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences [PDF]
, 2021 Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI) and deep learning.
arxiv +1 more source