Results 31 to 40 of about 10,658 (118)
Zebrafish as a Versatile Model Organism: From Tanks to Treatment
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava +9 more
wiley +1 more source
Developmental Dynamics, Volume 254, Issue 8, Page 887-901, August 2025.Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley +1 more source
Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors [PDF]
, 2015 The risk of insertional mutagenesis inherent to all integrating exogenous expression cassettes was the impetus for the development of various integration-defective lentiviral vector (IDLV) systems.
Hu, Peirong +4 more
core +4 more sources
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Eye &ENT Research, Volume 2, Issue 2, Page 104-115, June 2025.Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng +5 more
wiley +1 more source
Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism [PDF]
, 2014 Iron, copper, zinc, and eight other minerals are classified as essential trace elements because they present in minute in vivo quantities and are essential for life.
Fudi Wang, Lu Zhao, Zhidan Xia
core +1 more source
Development, Growth &Differentiation, Volume 67, Issue 5, Page 245-269, June 2025.Transcriptome analysis of pou5f3‐regulated genes in zebrafish embryos showed that competence to pou5f3 regulation changes significantly before and after the end of epiboly. The target genes encoded a diverse array of proteins, including transcriptional regulators and signaling molecules.
Masaaki Ikeda +6 more
wiley +1 more source
Identification of T-cell receptor a-chain genes in the chicken [PDF]
, 1994 T-cell receptor (TCR) -chain (TCR) and ß-chain (TCRß) genes are well characterized in mammals, while only TCRß genes have been identified in other vertebrates. To identify avian TCR genes, we used monoclonal anti-CD3 antibodies to isolate chicken TCR for
Aebersold, Ruedi +7 more
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