Results 31 to 40 of about 1,156 (60)
Animal Models and Experimental Medicine, Volume 7, Issue 6, Page 868-880, December 2024.Animal models have played a key role in neuroscience research for years. Nevertheless, their usage brings up ethical and transability issues concerning humans. In the recent years, alternative approaches have been developed, containing a potential for replacement and reduction of animal experimenting, associated with more relatable results. This review
Sabina Neziri +4 more
wiley +1 more source
The S2 Pocket Governs the Genus‐Specific Substrate Selectivity of Coronavirus 3C‐Like Protease
Advanced Science, Volume 11, Issue 44, November 26, 2024.This study reveals the critical role of the S2 pocket in coronavirus 3C‐like protease (CoV 3CLpro) for substrate selectivity and its variability across CoV genera. Analysis of ancestral and modern 3CLpros sheds light on evolutionary processes and their effect on the efficacy of PF‐07321332.
Junwei Zhou +11 more
wiley +1 more source
Environmental Toxicology and Chemistry, Volume 43, Issue 11, Page 2329-2337, November 2024.Abstract Adverse outcome pathways (AOPs) can aid with chemical risk assessment by providing plausible links between chemical activity at the molecular level and effect outcomes in intact organisms. Because AOPs can be used to infer causality between upstream and downstream events in toxicological pathways, the AOP framework can also facilitate ...
Monica K. Draskau +11 more
wiley +1 more source
Sequential SDF1a and b-induced mobility guides Medaka PGC migration [PDF]
, 2008 Assembly and formation of the gonad primordium are the first steps toward gonad differentiation and subsequent sex differentiation. Primordial germ cells (PGCs) give rise to the gametes that are responsible for the development of a new organism in the ...
Fischer, Peter +6 more
core +1 more source
Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland
Journal of Pineal Research, Volume 76, Issue 8, November 2024.ABSTRACT Located dorsally underneath a thin translucent skull in many teleosts, the pineal gland is a photoreceptive organ known as a key element of the circadian clock system. Nevertheless, the presence of additional routes of photoreception presents a challenge in determining its specific roles in regulating photic‐related behavior. Here, we show the
Yair Wexler +6 more
wiley +1 more source
Oocyte Activation Failure: Physiological and Clinical Aspects [PDF]
, 2019 Despite successful treatment of infertility with assisted reproductive technology (ART), total fertilization failure (TFF) after in vitro fertilization (IVF) and even after intracytoplasmic sperm injection (ICSI) still occurs. In the current chapter, the
Hojnik, Nina, Kovačič, Borut
core +2 more sources
Journal of Comparative Neurology, Volume 532, Issue 8, August 2024.We identify a novel ganglion cell type in marmoset retina, named tufted cell, which expresses the transcription factor Foxp2. Tufted cells are characterized by bare primary dendrites which branch frequently in the peripheral dendritic field to form dense tufts.
Sammy C. S. Lee +3 more
wiley +1 more source
Definitive hematopoiesis is autonomously initiated by the AGM region [PDF]
, 1996 The adult hematopoietic system of mammals is a dynamic hierarchy of cells with the hematopoietic stem cell at its foundation. During embryonic development, the source and expansion potential of this cell remain unclear.
Cumano +46 more
core +1 more source
American Journal of Reproductive Immunology, Volume 92, Issue 2, August 2024.ABSTRACT Since the advent of next‐generation sequencing, investigators worldwide have sought to discern whether a functional and biologically or clinically relevant prenatal microbiome exists. One line of research has led to the hypothesis that microbial DNA detected in utero/in ovo or prior to birth/hatching is a result of contamination and does not ...
Gwendolynn Hummel, Kjersti Aagaard
wiley +1 more source