Results 51 to 60 of about 573,263 (362)

Human pre-implantation embryo development

Development, 2012
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood.
Niakan, KK, Han, JN, Pedersen, RA, Simon, C, Pera, RAR   +4 more
openaire   +5 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integrative analysis of circulating microRNAs and the placental transcriptome in recurrent pregnancy loss

Frontiers in Physiology, 2022
Recurrent pregnancy loss (RPL) is a major type of pathological pregnancy that still lacks reliable early diagnosis and effective treatment. The placenta is critical to fetal development and pregnancy success because it participates in critical processes ...
Naixin Xu, Naixin Xu, Xuanyou Zhou, Xuanyou Zhou, Weihui Shi, Weihui Shi, Mujin Ye, Mujin Ye, Xianling Cao, Songchang Chen, Songchang Chen, Songchang Chen, Chenming Xu, Chenming Xu, Chenming Xu   +14 more
doaj   +1 more source

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
Achi, Aitken, Allsopp, Bailey, Baird, Betts, Blackburn, Cerone, de La Roche Saint-Andre, Dozortsev, Edwards, Evenson, Fiorenza, Fulka, G. M. Hartshorne, Gonzalo, H. P. Wong, Holt, Huang, J. Rai, Keefe, Keefe, Kimura, Lassalle, Liu, Liu, Liu, Longo, McIlrath, Meerdo, Morelli, Murnane, Rodr  guez, S. Turner, Schaetzlein, Tesarik, Valdes, Whitmire, Wong, Wright, Xu, Zhivkova, Zijlmans   +42 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Neuron development in human embryos [PDF]

Science, 2016
Human Biology Mammalian fertility depends on the secretion of gonadotropin-releasing hormone (GnRH) from a population of specialized neurons residing in the hypothalamus. During embryogenesis, these neurons develop at the olfactory placodes, and they subsequently migrate to the brain.
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome Patient

Frontiers in Cell and Developmental Biology, 2021
Down's syndrome (DS) is one of the most commonly known disorders with multiple congenital disabilities. Besides severe cognitive impairment and intellectual disability, individuals with DS also exhibit additional phenotypes of variable penetrance and ...
Yunjie Wang, Yunjie Wang, Zexu Li, Zexu Li, Guanheng Yang, Guanheng Yang, Linlin Cai, Linlin Cai, Fan Yang, Fan Yang, Yaqiong Zhang, Yaqiong Zhang, Yitao Zeng, Yitao Zeng, Qingwen Ma, Qingwen Ma, Fanyi Zeng, Fanyi Zeng, Fanyi Zeng   +18 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives

Frontiers in Endocrinology, 2022
A potential correlation between polycystic ovary syndrome (PCOS) and asthma, used to be identified as diseases originating from two independent systems, has been supported by increasing evidence. From an epidemiological perspective, mounting studies have
Yue Xu, Zhi-Yang Zhou, Jie-Xue Pan, He-Feng Huang, He-Feng Huang, He-Feng Huang   +5 more
doaj   +1 more source