Results 91 to 100 of about 315,208 (413)

Tracing the Evolution of Sex Hormones and Receptor‐Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease

Advanced Science, EarlyView.
Prostate and bladder cancers activate genes and pathways similar to those in the developmental stage by aggregating and analyzing current data. In this process, sex hormones and their receptors maybe a key role in causing and reversing the “cold” and “hot” immune tumor phenotypes, potentially enhancing the immune response.
Dengxiong Li, Zhipeng Wang, Qingxin Yu, Jie Wang, Ruicheng Wu, Zhouting Tuo, Koo Han Yoo, Dilinaer Wusiman, Luxia Ye, Yiqing Guo, Yubo Yang, Fanglin Shao, Ziyu Shu, Uzoamaka Okoli, William C. Cho, Wuran Wei, Dechao Feng   +16 more
wiley   +1 more source

Functional characterization of a novel TP53RK mutation identified in a family with Galloway–Mowat syndrome

Human Mutation, Volume 43, Issue 12, Page 1866-1871, December 2022., 2022
Abstract Galloway–Mowat syndrome (GAMOS) is a very rare condition characterized by early‐onset nephrotic syndrome and microcephaly with variable neurologic features. While considerable genetic heterogeneity of GAMOS has been identified, the majority of cases are caused by pathogenic variants in genes encoding the four components of the Kinase ...
Ernestine Treimer, Tugba Kalayci, Sven Schumann, Ilknur Suer, Sara Greco, Denny Schanze, Michael J. Schmeisser, Susanne J. Kühl, Martin Zenker   +8 more
wiley   +1 more source

Endogenous levels of reducing sugars, free amino acids and phenols during various stages of in vitro culture of cotton (Gossypium Spp.) [PDF]

, 2010
Somatic embryogenesis is widely preferred as the regeneration route for in vitro studies in cotton. However, the regeneration efficiency through this approach is low; a problem that is believed to be as a result of the biochemical properties of the ...
Obembe, Olawole O.
core  

Deep Reinforcement Learning of Cell Movement in the Early Stage of C. elegans Embryogenesis [PDF]

Bioinformatics, 2018, 2018
Cell movement in the early phase of C. elegans development is regulated by a highly complex process in which a set of rules and connections are formulated at distinct scales. Previous efforts have shown that agent-based, multi-scale modeling systems can integrate physical and biological rules and provide new avenues to study developmental systems ...
arxiv   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Integrated Environmental Assessment and Management, Volume 19, Issue 1, Page 63-82, January 2023., 2023
Abstract This review examines the presence and evolution of thyroid‐like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing.
Jane E. Morthorst, Henrik Holbech, Noémie De Crozé, Peter Matthiessen, Gerald A. LeBlanc   +4 more
wiley   +1 more source

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

Nature Communications
Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear.
Kanako Matsumoto, Yuki Akieda, Yukinari Haraoka, Naoki Hirono, Hiroshi Sasaki, Tohru Ishitani   +5 more
doaj   +1 more source

Correlation between metabolic depression and ecdysteroid peak during embryogenesis of the desert locust, Schistocerca gregaria (Orthoptera: Acrididae)

European Journal of Entomology, 2000
Respiratory metabolism of developing eggs of Schistocerca gregaria has been individually monitored by means of scanning microrespirography. The freshly oviposited eggs consumed 7 nl of O2 /min./egg (50 µl O2/g/h) while the pharate 1st instar larvae ...
Karel SLÁMA
doaj   +1 more source

THE DEGREE OF ACCUMULATION OF CADMIUM AND ZINC IN ADULT AND RAT EMBRYOS

Вісник проблем біології і медицини, 2020
Cadmium is a toxic heavy metal that is harmful to health. It has a pronounced tendency to accumulate in the body, including in the liver. Also has a toxic effect on embryo development.
Shamelashvili K. L.
doaj   +1 more source

Spatial mechanisms of gene regulation in metazoan embryos [PDF]

, 1991
The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core