Using giant scarlet runner bean embryos to uncover regulatory networks controlling suspensor gene activity. [PDF]
, 2015 One of the major unsolved issues in plant development is understanding the regulatory networks that control the differential gene activity that is required for the specification and development of the two major embryonic regions, the embryo proper and ...
Goldberg, Robert B, Henry, Kelli F
core +3 more sources
Genomic instability in individuals with sex determination defects and germ cell cancer
Cell Death Discovery, 2023 The ability to transmit genetic information through generations depends on the preservation of genome integrity. Genetic abnormalities affect cell differentiation, causing tissue specification defects and cancer.
Maria Krivega +8 more
doaj +1 more source
Journal of Microbiology & Biology Education, 2021 In classroom studies of mammalian embryology, students must fully grasp the cellular and tissue remodeling needed to initiate gastrulation to ensure comprehension of forthcoming developmental processes such as tissue specification and organogenesis ...
Ryan Hesterman +6 more
doaj +1 more source
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
Inhibition of DRP1 Impedes Zygotic Genome Activation and Preimplantation Development in Mice
Frontiers in Cell and Developmental Biology, 2021 Mitochondrion plays an indispensable role during preimplantation embryo development. Dynamic-related protein 1 (DRP1) is critical for mitochondrial fission and controls oocyte maturation.
Yuanyuan Li +4 more
doaj +1 more source
A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. [PDF]
, 2008 BackgroundActivated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans with complete deficiency of FX, and knockout of murine F10 is
Arruda, VR +7 more
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Control of globin gene expression by Kruppel-like factors [PDF]
, 2014 Kruppel-like factors (KLFs) are a family of seventeen proteins designated KLF1 to KLF17. KLFs are transcriptional factors that bind GC-rich sequences such as CACCC elements. The DNA binds to KLFs via three carboxyl-terminal Cys-2/His-2 zinc fingers. KLFs
Borg, Joseph, Grech, Laura
core +1 more source
Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage [PDF]
, 1996 The appearance of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formation of the germ ring, is one of the first signs of dorsoventral polarity in the zebrafish embryo.
Fraser, Scott E., Shih, John
core
Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster [PDF]
, 1937 Chromosome aberrations have marked effects upon the development of an organism. Many such aberrations are lethal. In Drosophila this is particularly true of chromosomal deficiencies, as first described by Bridges [2]. A more detailed study of the effects
Poulson, D. F.
core +1 more source
Human colon organoid differentiation from induced pluripotent stem cells using an improved method
FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee +4 more
wiley +1 more source