Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
The RNA-binding protein SRSF3 controls epicardial formation by regulating splicing and proliferation. [PDF]
DevelopmentLupu IE +8 more
europepmc +1 more source
Tunable 3D‐Printed Static Mixers for Gradient Bioprinting With High Cell Viability
Advanced Materials Technologies, EarlyView.ABSTRACT The fabrication of native tissue‐like structures with gradual transitions in material properties, cell types, and growth factors remains a major challenge in biofabrication due to the lack of suitable methods. Mimicking the hierarchical organization of living tissues is essential for functional models, yet creating gradient, multimaterial ...
Florian Hofmann +9 more
wiley +1 more source
Generation of Primordial Germ Cell-like Cells from hESCs Using BMP4 and hAFSC-Conditioned Medium. [PDF]
Methods ProtocArabadjiev B +3 more
europepmc +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Post-replicative chromatin accessibility predicts cell fate change. [PDF]
Stem Cell ReportsKnudsen TE +8 more
europepmc +1 more source
Advanced Materials Technologies, EarlyView.We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger +9 more
wiley +1 more source
Ascorbic acid enhances <i>in vitro</i> primordial germ cell-like cell differentiation from mouse ESCs. [PDF]
Front Cell Dev BiolKumar U +3 more
europepmc +1 more source
Skin‐Like Tri‐Modal Sensors Based on Soft Piezoelectric and Ionic Composites
Advanced Materials Technologies, EarlyView.Inspired by the multimodal perception of human skin, a soft, skin‐like tri‐modal sensor is presented. The device incorporates an ionically conductive, piezoelectric, elastic composite as its active layer, enabling independent detection of temperature, static strain, and dynamic strain within a single two‐terminal architecture.
Liren Wang +9 more
wiley +1 more source
Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells. [PDF]
Cell Mol Life SciPark KM, Yin R, Theunissen TW.
europepmc +1 more source