Results 31 to 40 of about 123,304 (256)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Infectious causes of embryonic and fetal mortality

open access: yesTheriogenology, 2008
The purpose of this review is to summarize bacterial, fungal, protozoan, and viral causes of reproductive dysgenesis in cattle, sheep, goats, pigs, horses, dogs, and cats. The clinical presentations of disease due to reproductive pathogens are emphasized, with a focus on assisting development of complete lists of causes that result in abortion and ...
Daniel Givens, M., Marley, M.S.D.
openaire   +2 more sources

EMBRYONIC MORTALITY IN THE POST-PARTURIENT DOMESTIC RABBIT [PDF]

open access: yesReproduction, 1973
Embryonic mortality in domestic rabbits ovulating in response to post-partum matings was investigated initially by Hammond (1925). In non-suckling does or does with small litters, pregnancies were successfully established soon after parturition and mortality appeared to be at a normal level.
G R, Foxcroft, H, Hasnain
openaire   +2 more sources

EFFECT OF SPRAYING HATCHING EGGS BY ASCORBIC ACID DURING INCUBATION ON HATCHABILITY, POST-HATCH CHICK GROWTH AND PHYSIOLOGICAL PARAMETERS IN A LOCAL STRAIN OF CHICKENS.

open access: yesEgyptian Poultry Science, 2014
The present study was carried out to investigate the effect of spraying hatching eggs with ascorbic acid (AA) on embryonic mortality, hatchability, growth performance of hatched chicks and some blood constituents as well as, economical efficiency of ...
doaj   +1 more source

Approaches to Identify Pregnancy Failure in Buffalo Cows

open access: yesAnimals, 2021
The aim of this work was to find the best strategy to diagnose pregnancy failures in buffalo. A total of 109 animals belonging to a buffalo herd subjected to a synchronization and artificial insemination (AI) program were enrolled in this study.
Vittoria Lucia Barile   +8 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Artificial stripping and embryonic development of the common gudgeon (Gobio gobio L.) and its use in embryo-larval tests - a pilot study

open access: yesCzech Journal of Animal Science, 2006
Artificial reproduction with and without hormonal treatment was performed in females of the common gudgeon (Gobio gobio L.) to assess the suitability of this cyprinid species as a fish model for embryo-larval cytotoxic tests.
M. Palíková, R. Krejčí
doaj   +1 more source

Congenital Malformations in Sea Turtles: Puzzling Interplay between Genes and Environment

open access: yesAnimals, 2021
The completion of embryonic development depends, in part, on the interplay between genetic factors and environmental conditions, and any alteration during development may affect embryonic genetic and epigenetic regulatory pathways leading to congenital ...
Rodolfo Martín-del-Campo   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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