Results 51 to 60 of about 123,304 (256)

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Evaluation of acute toxicity of neodymium and yttrium in zebrafish (Danio rerio) embryos

Frontiers in Environmental Science
Rare earth elements are a group of chemicals widely utilized in industry, leading to ecosystem contamination. Due to the lack of regulatory measures, there exists a considerable gap in knowledge concerning their potential to induce adverse effects in ...
Antonio Jesús Lora-Benítez, Ana María Molina-López, Rafael Mora-Medina, Jhon Edgardo Aguilar-Herrera, Nahúm Ayala-Soldado, Rosario Moyano-Salvago   +5 more
doaj   +1 more source

Avaliação biológica e econômica do uso de flunixin meglumine em vacas e novilhas de corte inseminadas em tempo fixo Biological and economic evaluation of flunixin meglumine in postpartum beef cows and heifers inseminated at fixed time

Revista Brasileira de Zootecnia, 2008
Objetivou-se verificar a redução de perdas embrionárias por meio do bloqueio da secreção de prostaglandina com a utilização de flunixin meglumine (FM) e avaliar o retorno econômico desta técnica.
Luiz Francisco Machado Pfeifer, Augusto Schneider, José Wilson da Silva Neto, Evâneo Alcides Ziguer, Nelson José Laurino Dionello, Marcio Nunes Corrêa   +5 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

MATERNAL AGEING AND EMBRYONIC MORTALITY IN THE RABBIT [PDF]

Reproduction, 1971
Summary. Progesterone and 20α-hydroxypregn-4-en-3-one (20α-P) synthesis in vivo and in vitro was measured 12 days post coitum in does averaging 32 weeks (young) and 214 weeks old (ageing). Young pregnant does had an average of 7·7 corpora lutea and 7·3 implantations for a mortality rate of 4·3%. Similar values for ageing does were 7·7,
R. R. MAURER, R. H. FOOTE
openaire   +2 more sources

The effects of hCG or GnRH treatment on embryonic mortality and reproductive performance in Buchi sheep of Cholistan desert, Pakistan [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
This study was conducted on Buchi sheep at Government livestock farm, Jugaitpeer, Bahawalpur, to investigate the birth and adult body weights, growth and turnover rates on reproductive performance.
M. Anam, M.H. Lashari, M.S. Akhtar, M. Abbas, K.A. Shahzad, A. Rubab, M. Kanwal, S. Tahreem, K.J. Alzahrani, K.F. Alsharif, F.M. Alzahrani   +10 more
doaj   +2 more sources

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Incubation characteristics of eggs from common quail (Coturnix coturnix)

Bulgarian Journal of Veterinary Medicine
The aim of the study was to investigate the main incubation characteristics of common quail (Coturnix coturnix) eggs, laid from industrially raised parental flocks.
T. Petrov, I. Gaydarova, H. Lukanov
doaj   +1 more source