Biology DirectBackground MicroRNA host gene (MIRHG) lncRNA is a particular lncRNA subclass that can perform both typical and atypical lncRNA functions. The biological function of MIRHG lncRNA MIR194-2HG in cancer is poorly understood.
Hong Cao +4 more
doaj +1 more source
Seeding hESCs to achieve optimal colony clonality [PDF]
arXiv, 2019 Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have promising clinical applications which often rely on clonally-homogeneous cell populations. To achieve this, cross-contamination and merger of colonies should be avoided. This motivates us to experimentally study and quantitatively model the growth of hESC colonies.
arxiv
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. [PDF]
, 1993 András Nagy +4 more
openalex +1 more source
Scientific ReportsChemotherapeutic agents can inhibit the proliferation of malignant cells due to their cytotoxicity, which is limited by collateral damage. Dihydroartemisinin (DHA), has a selective anti-cancer effect, whose target and mechanism remain uncovered.
Liu-Gen Li +11 more
doaj +1 more source
Identification and characterization of unique to human regulatory sequences in embryonic stem cells reveal associations with transposable elements, distal enhancers, non-coding RNA, and DNA methylation-driven mechanisms of genome editing [PDF]
arXiv, 2014 Despite significant progress in structural and functional characterization of human genome, understanding of mechanisms underlying the genetic basis of human phenotypic uniqueness remains limited. We report that non-randomly distributed transposable element-derived sequences, most notably HERV-H/LTR7 and L1HS, are associated with creation of 99.8 ...
arxiv
CTCF Degradation Causes Increased Usage of Upstream Exons in Mouse Embryonic Stem Cells [PDF]
arXiv, 2018 Transcriptional repressor CTCF is an important regulator of chromatin 3D structure, facilitating the formation of topologically associating domains (TADs). However, its direct effects on gene regulation is less well understood. Here, we utilize previously published ChIP-seq and RNA-seq data to investigate the effects of CTCF on alternative splicing of ...
arxiv
Constraints to Progress in Embryonic Stem Cells from Domestic Species [PDF]
, 2013 Domestic animal embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Unfortunately, despite many efforts, validated embryonic stem cell lines in species other than mice and primates ...
Caamaño, J.N. (José) +5 more
core
TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy
EpigeneticsMethylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogenes or tumour suppressor genes, thus contributing to ...
Ji Ren +6 more
doaj +1 more source
A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [PDF]
, 1990 Moshe Szyf +2 more
openalex +1 more source
Transition in cardiac contractile sensitivity to calcium during the in vitro differentiation of mouse embryonic stem cells. [PDF]
, 1994 Joseph M. Metzger +2 more
openalex +1 more source