Results 121 to 130 of about 1,123,946 (363)
Advanced Healthcare Materials, EarlyView.Segmented PCL‐bisurea (BU) polymers and BU‐peptide conjugate additives assemble into fibrous superstructures at the nanoscale through a mix‐and‐matching strategy. Different bioactivities are incorporated through variation of peptide sequences. The resulting materials are screened for their effect on stem cell adhesion and pluripotency.
Johnick F. van Sprang +6 more
wiley +1 more source
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. [PDF]
, 1991 Beverly H. Koller +7 more
openalex +3 more sources
Biology DirectBackground MicroRNA host gene (MIRHG) lncRNA is a particular lncRNA subclass that can perform both typical and atypical lncRNA functions. The biological function of MIRHG lncRNA MIR194-2HG in cancer is poorly understood.
Hong Cao +4 more
doaj +1 more source
Elasticity Maps of Living Neurons Measured by Combined Fluorescence and Atomic Force Microscopy [PDF]
E. Spedden, J.D. White, E.N. Naumova, D.L. Kaplan, C. Staii,
Elasticity Maps of Living Neurons Measured by Combined Fluorescence and
Atomic Force Microscopy, Biophysical Journal, Volume 103, Issue 5, 5
September 2012, Pages 868-877, 2013 Detailed knowledge of mechanical parameters such as cell elasticity, stiffness of the growth substrate, or traction stresses generated during axonal extensions is essential for understanding the mechanisms that control neuronal growth. Here we combine Atomic Force Microscopy based force spectroscopy with Fluorescence Microscopy to produce systematic ...
arxiv
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. [PDF]
, 1989 Beverly H. Koller +8 more
openalex +1 more source
Inorganic Nanomaterials Meet the Immune System: An Intricate Balance
Advanced Healthcare Materials, EarlyView.Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli +3 more
wiley +1 more source
Seeding hESCs to achieve optimal colony clonality [PDF]
arXiv, 2019 Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have promising clinical applications which often rely on clonally-homogeneous cell populations. To achieve this, cross-contamination and merger of colonies should be avoided. This motivates us to experimentally study and quantitatively model the growth of hESC colonies.
arxiv
The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]
, 1992 Paul Hasty +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A shrinkage‐resistant hydrogel is developed to confer post‐fabrication shape fidelity. The hydrogel, based on recombinant spider silk protein eADF4(C16)‐RGD and collagen‐I, exhibits tunable mechanical properties and shrink‐resistance in the presence of fibroblasts as well as muscle cells.
Xuen J. Ng +10 more
wiley +1 more source