The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa +11 more
core +3 more sources
This review explores functional and responsive materials for triboelectric nanogenerators (TENGs) in sustainable smart agriculture. It examines how particulate contamination and dirt affect charge transfer and efficiency. Environmental challenges and strategies to enhance durability and responsiveness are outlined, including active functional layers ...
Rafael R. A. Silva +9 more
wiley +1 more source
Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]
Objectives: Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca +8 more
core +2 more sources
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. [PDF]
Beverly H. Koller +8 more
openalex +1 more source
Thermoelectric temperature sensors are developed that directly measure heat changes during optical‐based neural stimulation with millisecond precision. The sensors reveal the temperature windows for safe reversible neural modulation: 1.4–4.5 °C enables reversible neural inhibition, while temperatures above 6.1 °C cause permanent thermal damage.
Junhee Lee +9 more
wiley +1 more source
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination [PDF]
Andreas Zimmer, Peter Gruss
openalex +1 more source
Embryonic Stem Cells: Introducing Exogenous Regulators into Embryonic Stem Cells [PDF]
The application of embryonic stem (ES) cells to research and therapy has been a landmark development in science. Cell therapy using ES cells depends on the progress of the stable culture conditions and differentiation induction methods. ES cells were first obtained directly from inner cell masses (ICMs) of blastocysts by Evans and Kaufman (1981), and ...
openaire +3 more sources
Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han +7 more
wiley +1 more source
An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai +9 more
wiley +1 more source

