Results 251 to 260 of about 566,277 (353)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation. [PDF]

Front Cell Dev Biol
Martinez-Alarcon O, Colin-Lagos D, Ramirez-Meza X, Castilla A, Hernandez-Montes G, Flores-Garza E, Lopez-Saavedra A, Avila-Gonzalez D, Martinez-Juarez A, Molina-Hernández A, Diaz-Martinez NE, Portillo W, Diaz NF.   +12 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Rat embryonic stem cell-based <i>in vitro</i> testing platform for mammalian embryo toxicology at pre- and post-implantation stages. [PDF]

Front Toxicol
Quadalti C, Moretti M, Ferrazzi F, Calzà L, Giardino L, Baldassarro VA.   +5 more
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Chromosome-specific aberrations, rather than general aneuploidy, may drive mouse embryonic stem cell-derived teratoma metastasis. [PDF]

Stem Cell Res Ther
Montilla-Rojo J, Hillenius S, Eleveld TF, Salvatori DCF, Looijenga LHJ.   +4 more
europepmc   +1 more source

Cardiac tissue inhibitor of matrix metalloprotease 4 dictates cardiomyocyte contractility and differentiation of embryonic stem cells into cardiomyocytes: Road to therapy

, 2015
Pankaj Chaturvedi, Anuradha Kalani, Anastasia Familtseva, Pradip K. Kamat, Naira Metreveli, Suresh C. Tyagi   +5 more
openalex   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Influence and Optimization of Diverse Culture Systems on Chicken Embryonic Stem Cell Culture. [PDF]

Genes (Basel)
Ren W, Wu J, Lu X, Zheng D, Liu G, Wu G, Peng Y, Jin K, Li G, Han W, Cui XS, Chen G, Li B, Niu YJ.   +13 more
europepmc   +1 more source

Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells.

, 2013
Xingrong Yan, Yanhong Yang, Wei Liu, Wenxin Geng, Huichong Du, Jihong Cui, Xin Xie, Jinlian Hua, Shumin Yu, Liwen Li, Fulin Chen   +10 more
openalex   +1 more source