Results 41 to 50 of about 1,359,697 (399)

Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation

Stem Cell Reports, 2016
Human embryonic stem cells (hESCs) can be maintained in a fully defined niche on extracellular matrix substrates, to which they attach through integrin receptors.
Loriana Vitillo, Melissa Baxter, Banu Iskender, Paul Whiting, Susan J. Kimber   +4 more
doaj   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Cell & Bioscience, 2023
Background Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 in cancers remains unknown to date.
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin   +7 more
doaj   +1 more source

Tracking the embryonic stem cell transition from ground state pluripotency

Development, 2016
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency.
Tüzer Kalkan, Nelly N Olova, M. Roode, C. Mulas, Heather J. Lee, Isabelle Nett, H. Marks, Rachael Walker, H. Stunnenberg, K. Lilley, J. Nichols, W. Reik, P. Bertone, A. Smith   +13 more
semanticscholar   +1 more source

Stem Cells from a Biological Perspective in Animals: A Review [PDF]

, 2017
Cells are the smallest living units of living system. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce more stem cells.
Jain, A. (Archana), Khan, M. A. (M), Shakkarpude, J. (J)   +2 more
core   +1 more source

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +2 more sources

Clinical applications of stem cell-derived exosomes

Signal Transduction and Targeted Therapy
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation.
Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, K. Shahzad, Jialin C. Zheng   +5 more
semanticscholar   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Journal of Immunology Research, 2020
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a
Xue-Feng Li, Zhi-Zhen Huang, Yuan-Yuan Hu, Yu-Ming Niu, Jun-Wei Cai   +4 more
doaj   +1 more source

Loss of stem cell regenerative capacity within aged niches. [PDF]

, 2007
This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells.
Carlson, Morgan, CONBOY, Irina M
core   +3 more sources