Results 41 to 50 of about 1,293,017 (382)

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

Tracking the embryonic stem cell transition from ground state pluripotency

Development, 2016
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency.
Tüzer Kalkan, Nelly N Olova, M. Roode, C. Mulas, Heather J. Lee, Isabelle Nett, H. Marks, Rachael Walker, H. Stunnenberg, K. Lilley, J. Nichols, W. Reik, P. Bertone, A. Smith   +13 more
semanticscholar   +1 more source

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Journal of Immunology Research, 2020
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a
Xue-Feng Li, Zhi-Zhen Huang, Yuan-Yuan Hu, Yu-Ming Niu, Jun-Wei Cai   +4 more
doaj   +1 more source

The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]

, 2015
Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC, Bayer SA, Brenner DJ, Cox J, Crumpton MJ, Ding GR, Draper G, Elizabeth Ainsbury, Fedele G, Gatz SA, Greenland S, International Agency for Research on Cancer (IARC), Ivancsits S, Jackie Haines, Kabacik S, Lagroye I, Lara Barazzuol, Lisa Woodbine, Luukkonen J, Luukkonen J, Maeda K, Mairs RJ, Margaret Coster, Mettler FA, Mitsuhashi T, O’Dea AR, Penny Jeggo, Pontious A, World Health Organization (WHO), Zenon Sienkiewicz, Zhao L   +30 more
core   +2 more sources

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson, Belotti D, Buske C, Deschamps J, Edwina Dobbin, Glenda J. Dickson, Helen Wheadon, Joanne M. Ramsey, Lawrence HJ, Pamela M. Corrigan, Robin W. Freeburn   +10 more
core   +1 more source

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Cell Death and Disease, 2022
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1-
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin   +9 more
doaj   +1 more source

The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy

Journal of Translational Medicine, 2023
Background Clinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of L-periaxin can be involved in CMT type 4F (CMT4F) by destroying the myelin sheath form, which may be related to ...
Ruo-nan Zhang, Xin Bao, Yun Liu, Yan Wang, Xing-Yuan Li, Ge Tan, Magdaleena Naemi Mbadhi, Wei Xu, Qian Yang, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu, Shan Li, Shao-juan Chen, Shi-you Chen, Jing Lv, Liu-liu Shi, Jun-ming Tang   +21 more
doaj   +1 more source

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.

European Heart Journal, 2015
AIMS Comparative studies suggest that stem cells committed to a cardiac lineage are more effective for improving heart function than those featuring an extra-cardiac phenotype.
P. Menasché, V. Vanneaux, A. Hagège, A. Bel, B. Cholley, Isabelle Cacciapuoti, Alexandre Parouchev, N. Benhamouda, G. Tachdjian, L. Tosca, J. Trouvin, J. Fabréguettes, V. Bellamy, R. Guillemain, C. Suberbielle Boissel, E. Tartour, M. Desnos, J. Larghero   +17 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Review of The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy (Basic Bioethics), edited by Suzanne Holland, Karen Lebacqz, and Laurie Zoloth [PDF]

, 2002
[Excerpt] Perhaps like others, I started The Human Embryonic Stem Cell Debate not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined.
Steele, James
core   +1 more source