Results 21 to 30 of about 315,544 (269)

Hadassah, provider of 'Regulatory-Ready' pluripotent clinical-grade stem cell banks

Stem Cell Research, 2020
The Hadassah hESC Research Center's aim is to be a supplier of clinical and research-grade human embryonic stem cell (hESC) lines. In 2012, we derived the first three entirely GMP-compliant and xeno-free, fully-characterised, feeder-dependent (human ...
Shelly E Tannenbaum, Orna Singer, Yaniv Gil, Yael Berman-Zaken, Nili Ilouz, Hanita Khaner, Miriam Haimov, Benjamin E Reubinoff   +7 more
doaj   +1 more source

Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis

Oncogenesis, 2023
The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood.
Yujiu Gao, Yue Yuan, Shu Wen, Yanghui Chen, Zongli Zhang, Ying Feng, Bin Jiang, Shinan Ma, Rong Hu, Chen Fang, Xuzhi Ruan, Yahong Yuan, Xinggang Fang, Chao Luo, Zhongji Meng, Xiaoli Wang, Xingrong Guo   +16 more
doaj   +1 more source

Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation

Stem Cell Reports, 2016
Human embryonic stem cells (hESCs) can be maintained in a fully defined niche on extracellular matrix substrates, to which they attach through integrin receptors.
Loriana Vitillo, Melissa Baxter, Banu Iskender, Paul Whiting, Susan J. Kimber   +4 more
doaj   +1 more source

Vagus nerve stimulation‐induced stromal cell‐derived factor‐l alpha participates in angiogenesis and repair of infarcted hearts

ESC Heart Failure, 2023
Aims We aim to explore the role and mechanism of vagus nerve stimulation (VNS) in coronary endothelial cells and angiogenesis in infarcted hearts. Methods and results Seven days after rat myocardial infarction (MI) was prepared by ligation of the left ...
Yan Wang, Yun Liu, Xing‐yuan Li, Lu‐yuan Yao, MagdaleenaNaemi Mbadhi, Shao‐Juan Chen, Yan‐xia Lv, Xin Bao, Long Chen, Shi‐You Chen, Jing‐xuan Zhang, Yan Wu, Jing Lv, Liu‐liu Shi, Jun‐ming Tang   +14 more
doaj   +1 more source

Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens

Frontiers in Microbiology, 2021
Antibiotic-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) has become a serious threat to public health worldwide.
Xudong Luo, Xudong Luo, Xiangdong Ye, Xiangdong Ye, Li Ding, Li Ding, Wen Zhu, Pengcheng Yi, Zhiwen Zhao, Huanhuan Gao, Zhan Shu, Shan Li, Ming Sang, Jue Wang, Weihua Zhong, Zongyun Chen, Zongyun Chen   +16 more
doaj   +1 more source

Embryonic stem cell proteomics

Expert Review of Proteomics, 2006
Human embryonic stem cells potentially represent an unlimited source of cells and tissues for regenerative medicine. Understanding signaling events that drive proliferation and specialization of these cells into various differentiated derivatives is of utmost importance for controlling their behavior in vitro. Major progress has been made in unraveling
van Hoof, D., Mummery, C.L., Heck, A.J.R., Krijgsveld, J.   +3 more
openaire   +4 more sources

Embryonic Stem Cell Markers [PDF]

Molecules, 2012
Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells. Understanding of the functions of these markers is critical for characterization and elucidation for the mechanism of ESC pluripotent maintenance and self-renewal, therefore helping to accelerate the clinical application of ES cells.
Lan Ma, Liang Li, Wenxiu Zhao, Xiang Ji, Fangfang Zhang   +4 more
openaire   +3 more sources

Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Cell & Bioscience, 2023
Background Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 in cancers remains unknown to date.
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin   +7 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source