Results 11 to 20 of about 350,335 (318)

An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs

Frontiers in Genetics, 2020
BackgroundDirect transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus.
Shinan Ma, Mengjie Yang, Mengjie Yang, Wenhui Zhou, Longjun Dai, Longjun Dai, Yan Ding, Xingrong Guo, Yahong Yuan, Junming Tang, Dongsheng Li, Xiaoli Wang   +11 more
doaj   +1 more source

Generation of C57BL/6 knockout mice using C3H × BALB/c blastocysts

BioTechniques, 2008
The International Mouse Knockout Consortium aims to generate a knockout mouse for every single gene on a C57BL/6 background. Our ability to generate such mice is hampered by the poor economics of producing blastocysts to achieve germline transmission of ...
Gabriela Pacholczyk, Rupali Suhag, Magdalena Mazurek, Suzanne M. Dederscheck, Pandelakis A. Koni   +4 more
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MicroRNAs in embryonic stem cells [PDF]

Journal of Cellular Physiology, 2008
AbstractThe unique properties of embryonic stem cells (ESCs) to self‐renew indefinitely or to differentiate to any cell type have great potential for clinical applications in regenerative medicine. MicroRNAs (miRNAs) are emerging as important regulators of post‐transcriptional gene expression and have been implicated as crucial elements in regulating ...
Yulei, Wang, David N, Keys, Janice K, Au-Young, Caifu, Chen   +3 more
openaire   +2 more sources

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
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ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
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Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
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Embryonic Stem Cell.

Internal Medicine, 2001
Mouse embryonic stem (ES) cells are the cells that possess pluripotential differentiation activity into not only all somatic cells but also germ cells. Genetic alteration of mouse ES cells can be easily achieved and such genetic modification can be introduced into the animal, since ES cells are differentiated into germ cells in vivo.
SATO, Masatake, NAKANO, Toru
openaire   +3 more sources

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Glenda J. Dickson, Pamela M. Corrigan, Freeburn, R.W., Robin W. Freeburn, Dickson, Glenda, Thompson, Alexander, Ramsey, Joanne, Helen Wheadon, Wheadon, H., Dickson, G.J., Edwina Dobbin, Alexander Thompson, Ramsey, J.M., Corrigan, P.M., Joanne M. Ramsey, Dobbin, E., Thompson, A.   +16 more
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Genesis of embryonic stem cells [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003
Embryonic stem (ES) cells are permanent pluripotent stem cell lines established from pre–implantation mouse embryos. There is currently great interest in the potential therapeutic applications of analogous cells derived from human embryos.
Mia, Buehr, Austin, Smith
openaire   +2 more sources