Results 41 to 50 of about 350,335 (318)

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION.

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Polgár, Zsuzsanna, Varga, Eszter, Klincumhom, Nuttha, Dinnyés, András, Nemes, Csilla, Pirity, Melinda K.   +5 more
core   +1 more source

Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction [PDF]

, 2010
The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Greenhough, Sebastian, Medine, Claire N, Hay, David C; id_orcid, Sharma, Ruchi   +3 more
core   +1 more source

Avian Embryonic Stem Cells [PDF]

, 2006
Blastodermal cells derived from the area pellucida of a stage X (EG&K) embryo have the potential to contribute to the somatic tissues and the germ line when reintroduced into a stage X (EG&K) recipient embryo. This chapter describes a method to culture chicken embryonic stem (cES) cells derived from blastodermal cells. Within the first week of culture,
Marie-Cecile, van de Lavoir, Christine, Mather-Love   +1 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.

, 2013
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine ...
Kingham, Emma Jayne, Richard O.C. Oreffo, Oreffo, Richard O.C., Emmajayne Kingham   +3 more
core   +1 more source

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]

, 2010
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S., Nicole M. Kane, Fergus R. McKenzie, Kane, N.M., Achamma Abraham, George S. Baillie, Allcock, R.W., John McAbney, Peter Burton, Baillie, G.S., Graeme Milligan, Kane, Nicole M., Houslay, Miles D., Andrew H. Baker, Robert W. Allcock, Gilmour, J., Gilmour, Jane, Mountford, Joanne C., Joanne C. Mountford, Jiang, Zhong, Miles D. Houslay, Adams, D.R., Adams, David R., McAbney, J., McCahill, Angela, Milligan, Graeme, McKenzie, F.R., Burton, Peter, Abraham, Achamma, Baker, Andrew H., McCahill, A., Jane Gilmour, Jiang, Z., Baker, A.H., Mountford, J.C., Angela McCahill, Abraham, A., Houslay, M.D., McAbney, John, McKenzie, Fergus R., Burton, P., David R. Adams, Milligan, G., Allcock, Robert W., Zhong Jiang   +44 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]

, 2006
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Joanne Crossley, Crossley, J., Andrew Godfrey, Takeuchi, Y., Clements, M.O., Boshoff, C., Godfrey, A., Mark O. Clements, Sam J. Wilson, Wilson, S.J., Yasu Takeuchi, Chris Boshoff   +11 more
core   +1 more source

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Journal of Immunology Research, 2020
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a
Xue-Feng Li, Zhi-Zhen Huang, Yuan-Yuan Hu, Yu-Ming Niu, Jun-Wei Cai   +4 more
doaj   +1 more source

Immunosuppression by Embryonic Stem Cells [PDF]

Stem Cells, 2007
AbstractEmbryonic stem cells or their progeny inevitably differ genetically from those who might receive the cells as transplants. We tested the barriers to engraftment of embryonic stem cells and the mechanisms that determine those barriers. Using formation of teratomas as a measure of engraftment, we found that semiallogeneic and fully allogeneic ...
Cody A, Koch, Pedro, Geraldes, Jeffrey L, Platt   +2 more
openaire   +2 more sources