Results 71 to 80 of about 1,324,654 (403)

Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements

Toxins
Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also ...
Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo   +11 more
doaj   +1 more source

Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by Random Circuit Perturbation [PDF]

arXiv, 2020
Stem cells can precisely and robustly undergo cellular differentiation and lineage commitment, referred to as stemness. However, how the gene network underlying stemness regulation reliably specifies cell fates is not well understood. To address this question, we applied a recently developed computational method, Random Circuit Perturbation (RACIPE ...
arxiv  

The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]

, 2015
Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC, Bayer SA, Brenner DJ, Cox J, Crumpton MJ, Ding GR, Draper G, Elizabeth Ainsbury, Fedele G, Gatz SA, Greenland S, International Agency for Research on Cancer (IARC), Ivancsits S, Jackie Haines, Kabacik S, Lagroye I, Lara Barazzuol, Lisa Woodbine, Luukkonen J, Luukkonen J, Maeda K, Mairs RJ, Margaret Coster, Mettler FA, Mitsuhashi T, O’Dea AR, Penny Jeggo, Pontious A, World Health Organization (WHO), Zenon Sienkiewicz, Zhao L   +30 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]

, 2008
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core  

Neural tissue engineering using embryonic and induced pluripotent stem cells [PDF]

, 2011
With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural ...
Willerth, Stephanie M
core   +2 more sources

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Hematopoietic cancers and Nup98 fusions: determining common mechanisms of malignancy [PDF]

, 2012
Chromosomal aberrations are very frequent in leukemias and several recurring mutations capable of malignant transformation have been described. These mutations usually occur in hematopoietic stem cells (HSC), transforming them into leukemia stem cells.
arxiv   +1 more source

Computational analysis of expression of human embryonic stem cell-associated signatures in tumors [PDF]

, 2011
Background The cancer stem cell model has been proposed based on the linkage between human embryonic stem cells and human cancer cells. However, the evidences supporting the cancer stem cell model remain to be collected.
A Hsieh, A Murat, AB Celil, AM Singh, AT Collins, AY Olsson, B Bhattacharya, B Binetruy, BL Kidder, C Grandela, C Lambertini, C Li, C Li, C Liu, C Montagut, C Wicking, CA O'Brien, CL Efferson, CP Gibbs, D Besser, D Bonnet, D Fang, D James, DAG Card, DM Vallejo, E Quintana, EJ Allenspach, EJD Robson, F Wang, FC Kelleher, G Hu, G Stenman, G Yang, GV Glinsky, H Hirata, H Ikushima, H Miyazaki, H Mizuno, H Muller, H Qin, H Vaziri, HB Kang, I Ben-Porath, I Chambers, I Neganova, J Ji, J Kim, J Kim, J Massague, J Ren, J Taipale, J Vanamala, J Xie, J Yu, J-Y Rho, JA Kennedy, JA Williams, JM Carethers, JM Sperger, K Abdelmohsen, K Collins, K Sabapathy, K Smith, K Takahashi, K Yanai, KA Hassan, KV Tarasov, L Chavez, L Ricci-Vitiani, L Strizzi, L Vallier, L Wang, LA Boyer, LC Laurent, LH Hartwell, M Al-Hajj, M Bar, M Jung, M Katoh, M Malumbres, M Mimeault, M Richards, M Schoenhals, M Suzuki, M Vita, M Zoller, M-R Suh, MA Guvakova, ME Levenstein, MF Clarke, MJ Abeyta, MJ Murray, MV Hadjihannas, N Hu, N Liu, N Sato, NA Lobo, NE Sharpless, NE Sharpless, NS Lee, NV Varlakhanova, O Adewumi, P Dvorak, P Garcia, PA Beachy, PA Gregory, PB Gupta, PN Ghule, PN Kelly, Q Huang, R Brandenberger, R Derynck, R Margueron, R Pardal, R Simon, RA Young, RD Morin, RG Ramsay, RI Skotheim, RJ Akhurst, RJAM Michalides, RM Marion, RR Rao, RT Oliver, S Assou, S Liu, S Peng, S Roush, S Santagata, S Sell, S Terry, S Yehezkel, S Zhang, S-H Chiou, S-H Chiou, S-L Lin, S-L Lin, SA Bapat, SC Bendall, SE Artandi, SJ Zardawi, SK Mallanna, SK Singh, SK Singh, SL Rose, SM Bokobza, SN Constantinescu, T Burdon, T Izycki, T Kawamura, T Lapidot, T Reya, T Reya, TI Lee, U Ben-David, U Lakshmipathy, V Bolos, V Kashyap, V Shukla, V Velcheti, VK Gangaraju, VN Anisimov, W Cui, W Niklinska, W Wagner, X Chen, X Chen, X Li, X-m Zhang, Xiaosheng Wang, Y Babaie, Y Katoh, Y Shimono, Y Sun, Y Wang, Y Zhang, Y Zhao, Z Song, Z Wang   +178 more
core   +4 more sources

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury

Journal of Neuroscience, 2005
Demyelination contributes to loss of function after spinal cord injury, and thus a potential therapeutic strategy involves replacing myelin-forming cells.
H. Keirstead, G. Nistor, G. Bernal, Minodora O. Totoiu, Frank Cloutier, K. Sharp, O. Steward   +6 more
semanticscholar   +1 more source