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Stem Cells and Development, 2007
Stem cells are unique cell populations with the ability to choose between self-renewal and differentiation. Embryonic stem (ES) cells have the ability to form any fully differentiated cell of the body. To date, only three species of mammals have yielded long-term cultures of self-renewing ES cells- mice, monkeys, and humans.
Atindriya Biswas, R. Hutchins
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Stem cells are unique cell populations with the ability to choose between self-renewal and differentiation. Embryonic stem (ES) cells have the ability to form any fully differentiated cell of the body. To date, only three species of mammals have yielded long-term cultures of self-renewing ES cells- mice, monkeys, and humans.
Atindriya Biswas, R. Hutchins
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Stem Cell Reviews, 2006
Embryonic stem (ES) cells are pluripotent cells that can be isolated and grown in vitro from the inner cell mass of blastocysts. Their potential to differentiate into any cell of the body makes them a promising starting material for cell therapy.
Frank Buchholz, Li Ding
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Embryonic stem (ES) cells are pluripotent cells that can be isolated and grown in vitro from the inner cell mass of blastocysts. Their potential to differentiate into any cell of the body makes them a promising starting material for cell therapy.
Frank Buchholz, Li Ding
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2014
Preimplantation embryo development sets the stage for pluripotency Regenerative medicine has the potential to revolutionize health care by offering the promise of replacement cells, tissues, and organs to combat injury, disease, and aging. In an ideal setting, stem cell therapies would begin with a pluripotent cell that by definition is able to give ...
Irina Klimanskaya +2 more
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Preimplantation embryo development sets the stage for pluripotency Regenerative medicine has the potential to revolutionize health care by offering the promise of replacement cells, tissues, and organs to combat injury, disease, and aging. In an ideal setting, stem cell therapies would begin with a pluripotent cell that by definition is able to give ...
Irina Klimanskaya +2 more
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The Nature of Embryonic Stem Cells
Annual Review of Cell and Developmental Biology, 2014Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture but can reenter embryonic development seamlessly, differentiating on schedule to form all elements of the fetus.
MARTELLO, GRAZIANO, Austin Smith
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Pluripotency of embryonic stem cells
Cell and Tissue Research, 2007Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to differentiate into any cell type derived from the three germ layers of ectoderm (epidermal tissues and nerves), mesoderm (muscle, bone, blood), and endoderm (liver, pancreas, gastrointestinal tract, lungs), including fetal and adult cells.
Yamanaka, S +7 more
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Differentiation of Embryonic Stem Cells
Current Protocols in Neuroscience, 2009AbstractMouse embryonic stem (ES) cells are derived from mouse blastocyst and are able to generate all embryonic tissues in vitro. This propensity of ES cells has acquired considerable attention in recent years due to the promising potential for future cell replacement–based therapies.
Kerstin Krieglstein +4 more
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Embryonic stem cell lines derived from human blastocysts.
Science, 1998Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early ...
J. Thomson +6 more
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2013
Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
2018Birth defects are the leading cause of infant mortality in the USA, yet the causes of most of these conditions are unknown. While a combination of genetic and environmental factors are suspected in most cases, little information exists about the health risks that prenatal exposure to many common chemicals poses for the fetus.
Darcie L V McClelland-Descalzo +2 more
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