Results 231 to 240 of about 1,274,889 (380)

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway. [PDF]

Mol Med
Haddad A, Golan-Lev T, Benvenisty N, Goldberg M.   +3 more
europepmc   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

CXXC5 stabilizes DNA methylation patterns in mouse embryonic stem cells. [PDF]

Epigenomics
Jin SG, Johnson J, Huang Z, Cui W, Dunwell T, Pfeifer GP.   +5 more
europepmc   +1 more source

A Cre-lox recombination system for the targeted integration of circular yeast artificial chromosomes into embryonic stem cells [PDF]

, 2000
Linda Call
openalex   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Advances in development of long-term embryonic stem cell-like cultures from a marine fish, Sciaenops ocellatus

Current Research in Food Science
The overall goal of our research was to develop an embryonic stem cell line from red drum, Sciaenops ocellatus. These experiments were conducted to support future production of cell-based cultivated seafood products as a means towards meeting the growing
Catherine J. Walsh, Nicole Rhody, Kevan L. Main, Jessica Restivo, Andrea M. Tarnecki   +4 more
doaj  

H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells. [PDF]

Epigenetics Chromatin
Patty BJ, Jordan C, Lardo SM, Troy K, Hainer SJ.   +4 more
europepmc   +1 more source

Retro-recombination screening of a mouse embryonic stem cell genomic library [PDF]

, 2000
Knut Woltjen, Gretchen Bain, Derrick E. Rancourt   +2 more
openalex   +1 more source

3D‐Printed Biomimetic Vascular Scaffold Crosslinked with Heparan Sulfate for Sustained Release of PDGFB‐LG4 Fusion Protein Promotes Bone Regeneration

Advanced Science, EarlyView.
Fusion protein PDGFB‐LG4 exhibits superior osteoinductive and angiogenic activity compared to PDGFB. The PCLHS‐PDGFB‐LG4 scaffold, featuring perfusable and permeable vascular‐like networks, promotes angiogenesis and osteogenesis through the sustained release of PDGFB‐LG4, thereby accelerating the bone defect repair process.
Jiahua Duan, Gaofei Qian, Huikang Zhang, Feifan Wang, Qiang Tian, Dong Lei, Jianning Zhao   +6 more
wiley   +1 more source