Results 241 to 250 of about 5,338,715 (307)

Nicotinamide salvage is required for proliferation and sustaining self-renewal in undifferentiated embryonic stem cells. [PDF]

Stem Cells
Lu MJ, Chan HR, Deme S, Oliphint PA, Kim J, Allard P, Cambronne XA.   +6 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Derivation of embryonic stem cells across avian species. [PDF]

Nat Biotechnol
Chen X, Guo Z, Tong X, Wang X, Liu X, Nagai H, Wu P, Lu J, Huss D, Tran M, Readhead C, Wu C, Cao L, Huang Y, Zeng Z, Feng F, Adhami N, Mor S, Lansford R, Chuong CM, Sheng G, Lois C, Ying QL.   +22 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Correction: In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells. [PDF]

Reprod Biol Endocrinol
Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H.   +17 more
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Attenuated innate immunity in embryonic stem cells: mechanisms and therapeutic applications. [PDF]

Cell Biosci
Chen S, Wang R, Yang J, Zhou X, Shen S, Li H, Zhang X, Chen W, Xie Q.   +8 more
europepmc   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Landscape of microRNA and target expression variation and covariation in single mouse embryonic stem cells. [PDF]

Genome Res
Tarbier M, Mackowiak SD, Sekar V, Bonath F, Yapar E, Fromm B, Faridani OR, Biryukova I, Friedländer MR.   +8 more
europepmc   +1 more source

Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation potency in embryonic stem cells. [PDF]

Exp Mol Med
Nam YJ, Kwon H, Im HJ, Rahman N, Lubna H, Lee S, Ahn HS, Jang G, Kim Y, Ju H, Ha SW, Kim HJ, Lee D, Park SJ, Song SH, Park J, Kim Y, Choi Y, Kim K, Shin DM, Lee S.   +20 more
europepmc   +1 more source