Results 281 to 290 of about 571,903 (350)

Understanding the ethical concerns that have shaped European regulation of human embryonic stem cell research

, 2012
Heidi Mertes
openalex   +1 more source

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

Advanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang, Honglin Tan, Colleen Russell, Mikolaj Walczak, Dawei Gao, Guanda Qiao, Xiaoxuan Fan, Chengyan Chu, Miroslaw Janowski, Piotr Walczak, Yajie Liang   +10 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells. [PDF]

FEBS Open Bio
Amel A, Brown R, Rabeling A, Goolam M.
europepmc   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells

Dimova-Vasileva S, Stepanova O, Hay D, Pickup KE, Gautier P, Murphy LC, Kumar Y, Adams IR, Pennings S, Meehan RR.   +9 more
europepmc   +1 more source

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses. [PDF]

Nat Commun
Dong H, Pan Z, Jiao P, Ye F, Peng Q, Yu Y, Lai X, Li H, Guan Z, Deng J, Shen T, Tan W, Shi Y, Ding Q, Luo J, Li T, Zhuang H, Xiang K.   +17 more
europepmc   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Regulation of PKCi-mediated pluripotency and gene expression by polycomb complex 1 in mouse embryonic stem cells. [PDF]

Am J Transl Res
Wu F, Liu Z, Wu X, Li J, Chen X, Yang L, Du F.   +6 more
europepmc   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells. [PDF]

Stem Cell Reports
Yan J, Luo R, Rosen BP, Liu D, Wong W, Leslie CS, Huangfu D.   +6 more
europepmc   +1 more source