Results 1 to 10 of about 204,941 (177)

Tatouage audio par EMD [PDF]

open access: yesIEEE Transactions on Audio, Speech, and Language Processing, 2013
In this paper a new adaptive audio watermarking algorithm based on Empirical Mode Decomposition (EMD) is introduced. The audio signal is divided into frames and each one is decomposed adaptively, by EMD, into intrinsic oscillatory components called ...
BOUDRAA, Abdel-Ouahab, KHALDI, Kais
core   +8 more sources

A Modified Noise-Resistant Trend Estimation Method Based on EMD and SSA for Aeroelastic Aircraft Systems [PDF]

open access: yesAUT Journal of Modeling and Simulation, 2021
Aimed at the nonlinear system identification of aeroelastic aircraft, the signal decomposition methods are required to extract the contributing natural and non-standard flight modes from flight test data, especially in the presence of flight noise.
Seyed Amin Bagherzadeh   +1 more
doaj   +1 more source

Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding

open access: yesOncoImmunology, 2021
Avelumab is an IgG1 anti–programmed death ligand 1 (anti–PD-L1) monoclonal antibody that has been approved as a monotherapy for metastatic Merkel cell carcinoma and advanced urothelial carcinoma, and in combination with axitinib for advanced renal cell ...
Hulin Jin   +12 more
doaj   +1 more source

Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases

open access: yesFrontiers in Immunology, 2023
Autoimmune diseases vary in the magnitude and diversity of autoantibody profiles, and these differences may be a consequence of different types of breaks in tolerance.
Thomas Clarke   +15 more
doaj   +1 more source

Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach

open access: yesClinical and Translational Science, 2022
Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β “trap”) fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy
Yulia Vugmeyster   +5 more
doaj   +1 more source

Bispecific antibodies: A guide to model informed drug discovery and development

open access: yesHeliyon, 2021
Affinity (KD) optimization of monoclonal antibodies is one of the factors that impacts the stoichiometric binding and the corresponding efficacy of a drug.
Irina Kareva   +3 more
doaj   +1 more source

Identifying lupus Patient Subsets Through Immune Cell Deconvolution of Gene Expression Data in Two Atacicept Phase II Studies

open access: yesACR Open Rheumatology, 2023
Objective To use cell‐based gene signatures to identify patients with systemic lupus erythematous (SLE) in the phase II/III APRIL–SLE and phase IIb ADDRESS II trials most likely to respond to atacicept.
Matthew Studham   +10 more
doaj   +1 more source

NHS-IL12 and bintrafusp alfa combination therapy enhances antitumor activity in preclinical cancer models

open access: yesTranslational Oncology, 2022
Combinatorial immunotherapy approaches are emerging as viable cancer therapeutic strategies for improving patient responses and outcomes. This study investigated whether two such immunotherapies, with complementary mechanisms of action, could enhance ...
Chunxiao Xu   +8 more
doaj   +1 more source

Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies

open access: yesScientific Reports, 2023
TL-895 (formerly known as M7583) is a potent, highly selective, adenosine triphosphate (ATP)-competitive, second-generation, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).
Samantha M. Goodstal   +13 more
doaj   +1 more source

Defect Detection Sensitivity of Bubble-Point-Type Tests for Sterilizing-Grade Membrane Cartridge Filters

open access: yesMembranes, 2023
Bubble point tests are widely used for assessing the integrity of sterilizing-grade membrane cartridge filters. While many authors have considered the limitations of bubble point tests as applied to cartridge filters, the level of bacterial retention ...
Sal Giglia   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy