Results 51 to 60 of about 205,040 (276)

Applying the Hilbert--Huang Decomposition to Horizontal Light Propagation C_n^2 data [PDF]

open access: yes, 2006
The Hilbert Huang Transform is a new technique for the analysis of non--stationary signals. It comprises two distinct parts: Empirical Mode Decomposition (EMD) and the Hilbert Transform of each of the modes found from the first step to produce a Hilbert ...
Chang, Mark P. J. L.   +4 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration‐QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers

open access: yesClinical and Translational Science, 2020
Bruton's tyrosine kinase (BTK) is a key regulator of B cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases.
Andreas Becker   +7 more
doaj   +1 more source

Codage des signaux par EMD [PDF]

open access: yes, 2012
In this letter a new signals coding framework based on the Empirical Mode Decomposition (EMD) is introduced. The EMD breaks down any signal into a reduced number of oscillating components called Intrinsic Modes Decomposition (IMFs).
BOUDRAA, Abdel-Ouahab, KHALDI, Kais
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Hydrocarbon detection based on empirical mode decomposition, teager-kaiser energy, and the cepstrum

open access: yesFrontiers in Earth Science, 2022
Seismic waves produce anomalies when they pass through hydrocarbons; these anomalies, which are commonly used to detect hydrocarbons, are manifested differently in different domains.
Xudong Jiang   +4 more
doaj   +1 more source

Modified detrended fluctuation analysis based on empirical mode decomposition

open access: yes, 2009
Detrended fluctuation analysis (DFA) is a simple but very efficient method for investigating the power-law long-term correlations of non-stationary time series, in which a detrending step is necessary to obtain the local fluctuations at different ...
Alessio   +53 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Electron momentum distribution in underdoped cuprates

open access: yes, 2000
We investigate the electron momentum distribution function (EMD) in a weakly doped two-dimensional quantum antiferromagnet (AFM) as described by the t-J model.
A. Rams̆ak   +31 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

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