Results 51 to 60 of about 141,430 (348)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Adaptive denoising of ECG using EMD, EEMD and CEEMDAN signal processing techniques
Journal of Physics: Conference Series, 2020 Using adaptive signal processing techniques denoising of ECG signal is performed which is obtained from physionet database. In this paper, the baseline wandering noise is removed using different adaptive techniques such as Empirical Mode Decomposition ...
Krishna Teja +2 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Clinical and Translational Science, 2020 Bruton's tyrosine kinase (BTK) is a key regulator of B cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases.
Andreas Becker +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Hydrocarbon detection based on empirical mode decomposition, teager-kaiser energy, and the cepstrum
Frontiers in Earth Science, 2022 Seismic waves produce anomalies when they pass through hydrocarbons; these anomalies, which are commonly used to detect hydrocarbons, are manifested differently in different domains.
Xudong Jiang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Research on vibration signal prediction of coal mine machinery
Gong-kuang zidonghua, 2020 According to variation differences of high frequency and low frequency components of coal mine machinery vibration signal, a combined vibration signal prediction method of coal mine machinery based on empirical mode decomposition (EMD) and support vector
XIAO Yajing, LI Xu, GUO Xi
doaj +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Development of a hybrid method for stock trading based on TOPSIS, EMD and ELM [PDF]
, 2022 Elivelto Ebermam +2 more
openalex +1 more source