Results 101 to 110 of about 1,791,218 (298)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Emergence in organizations: The reflexive turn
, 2010 In this paper we explore the role and meaning of the concept of emergence in the study of organizations. A brief recount of the history of the concept of emergence illustrates a general failure to distinguish between the mechanisms of emergence present ...
Kay, R, Goldspink, C
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Development Studies ResearchGrowing disparities in asset ownership and capital accumulation have raised concerns about the role of wealth inequality in shaping long-term development, particularly in low-income countries. Although the inequality–growth nexus has been widely studied,
Bocar Sidi Konaté, Said Hanchane
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and ManufacturingMotorcycle assistance systems have been an increasing focus of research in recent years to promote safer riding practices and mitigate motorcycle-related accidents.
Kifle Hailu GEBRETSADIK, Keisuke SUZUKI
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia
HeliyonBackground: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of ...
Mucahit Kapci +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The Ontology of Complex Systems: Wimsatt on Emergence
openThis dissertation aims to offer a perspective on Wimsatt's work, emphasizing its originality in addressing ontological issues related to emergence. The first section provides a concise overview of Wilson's concept of Weak Emergence, serving as common
LONGATO, ORSO LODOVICO
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Emerging Sight, Emerging Blindness
, 2012 This essay covers two main topics: the role of the “double vi-sion” of the sight/nonsight of blinking in selected fiction of Neil Gaiman and China Miéville, and an examination of the role of blindness and sight surrounding “Molyneux’s question.” In Gaiman’s work “double vision” functions as a synchronic representation of diachronic events.
openaire +1 more source