Results 111 to 120 of about 1,791,218 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The emergence of sustainability culture and the sustainability practitioner [PDF]

, 2012
In this thesis, I propose that sustainability is a new emergent cultural phenomenon – a new “dreaming” - arising from our conscious and unconscious actions, our relationships and our connection to place.
Parnell, Matthew
core  

Update on tick-borne pathogens detection methods within ticks

Current Research in Parasitology and Vector-Borne Diseases
Ticks are known vectors of various pathogens, including bacteria, parasites and viruses, that impact both animal and human health. Improving knowledge of the distribution of tick-borne pathogens, combined with their early detection in ticks, are ...
Eva Krupa, Alexis Dziedziech, Richard Paul, Sarah Bonnet   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Norm emergence in tag-based cooperation [PDF]

, 2010
In multi-agent systems norms are an important influence that can engender cooperation by constraining actions and binding groups together. A key question is how to establish a suitable set of norms in a decentralised population of self-interested agents,
Griffiths, N, Luck, M; id_orcid, Griffiths, Nathan, Luck, Michael (Michael M.)   +3 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tick exposure biomarkers: A One Health approach to new tick surveillance tools

Current Research in Parasitology and Vector-Borne Diseases
The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies.
Alexis Dziedziech, Eva Krupa, Kristina E.M. Persson, Richard Paul, Sarah Bonnet   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

“Noninvasive predictive marker for esophageal variceal bleeding”

BMC Gastroenterology
Objective Esophageal varices are common in cirrhosis with portal hypertension; some patients face high risk of life-threatening esophageal variceal bleeding (EVB).
Shuo Zhang, Tomohiko Akahoshi, Tomoharu Yoshizumi, Masatoshi Eto   +3 more
doaj   +1 more source