Results 121 to 130 of about 3,399,190 (337)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Emergence of Quasicondensates of Hard-Core Bosons at Finite Momentum [PDF]

, 2004
Marcos Rigol, Alejandro Muramatsu
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Detection of influenza virus in urban wastewater during the season 2022/2023 in Sicily, Italy

Frontiers in Public Health
IntroductionSeasonal influenza generally represents an underestimated public health problem with significant socioeconomic implications. Monitoring and detecting influenza epidemics are important tasks that require integrated strategies. Wastewater-based
Carmelo Massimo Maida, Carmelo Massimo Maida, Walter Mazzucco, Walter Mazzucco, Walter Priano, Roberta Palermo, Giorgio Graziano, Claudio Costantino, Claudio Costantino, Arianna Russo, Gina Andolina, Isabella Restivo, Viviana Giangreco, Francesca Rita Iaia, Arianna Santino, Rita Li Muli, Valeria Guzzetta, Francesco Vitale, Francesco Vitale, Fabio Tramuto, Fabio Tramuto   +20 more
doaj   +1 more source

Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda

Scientific Reports, 2017
Infections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for case management in resource-limited settings.
Anne-Laure Page, Yap Boum II, Elizabeth Kemigisha, Nicolas Salez, Deborah Nanjebe, Céline Langendorf, Said Aberrane, Dan Nyehangane, Fabienne Nackers, Emmanuel Baron, Rémi Charrel, Juliet Mwanga-Amumpaire   +11 more
doaj   +1 more source

Emergence of digital biomarkers to predict and modify treatment efficacy: machine learning study [PDF]

, 2019
Nicole L Guthrie, Jason M. Carpenter, Katherine L Edwards, Kevin J Appelbaum, Sourav Madhur Dey, David M. Eisenberg, David L. Katz, Mark A Berman   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Virus evolution : the emergence of new ideas (and re-emergence of old ones)

, 2006
Reputed intractable, the question of the origin of viruses has long been neglected. In the modern literature 'Virus evolution' has come to refer to study more akin to population genetics, such as the world-wide scrutiny on new polymorphisms appearing ...
Claverie, Jean-Michel
core  

Truthmaking and the Mysteries of Emergence [PDF]

, 2018
The concept of truthmaking, the idea that when a statement is true, there is typically something about the world in virtue of which it is true, has garnered much interest in recent metaphysics.
Morris, Kevin
core