Results 81 to 90 of about 3,144 (163)

IMPACT OF BETA‐DYSTROGLYCAN DEFICIENCY ON EMERIN FUNCTIONS

The FASEB Journal, 2018
Beta‐dystroglycan (b‐DG) is a plasma membrane protein that belongs to the dystrophin‐associated protein complex (DAPC), the latter provides a link between the extracellular matrix and the cytoskeleton. Previously we reported that b‐DG is translocated localized to the nucleus via recognition of its nuclear localization signal (NLS), located in the ...
Jesús Mauricio Ernesto Hernández Méndez, Wendy Lilián Gómez Monsiváis, Ricardo Mondragón González, Rita Perlingeiro, Jaime García Mena, Bulmaro Cisneros Vega   +5 more
openaire   +1 more source

An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells

Stem Cell Research, 2017
The ability of iPSCs (induced pluripotent stem cells) to generate any cell type in the body makes them valuable tools for cell replacement therapies. However, differentiation of iPSCs can be demanding, slow and variable.
Cecilia Bergqvist, Mohammed Hakim Jafferali, Santhosh Gudise, Robert Markus, Einar Hallberg   +4 more
doaj   +1 more source

An Intronic Heterozygous SYNE2 Splice Site Mutation: A Rare Cause for Myalgia and hyperCKemia?

Muscles
SYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-exome
Theresa Paulus, Natalie Young, Emily Jessop, Carolin Berwanger, Christoph Stephan Clemen, Rolf Schröder, Rafal Ploski, Christian Hagel, Yorck Hellenbroich, Andreas Moser, Iakowos Karakesisoglou   +10 more
doaj   +1 more source

A Novel Mutation Of The EMD Gene In A Family With Cardiac Conduction Abnormalities And A High Incidence Of Sudden Cardiac Death

Pharmacogenomics and Personalized Medicine, 2019
Demiao Kong,1,2,* Yi Zhan,3,* Canzhao Liu,4 Yerong Hu,1 Yangzhao Zhou,1,4 Jiawen Luo,1 Lu Gu,1 Xinmin Zhou,1 Zhiwei Zhang1,4 1Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China ...
Kong D, Zhan Y, Liu C, Hu Y, Zhou Y, Luo J, Gu L, Zhou X, Zhang Z   +8 more
doaj  

Emery–Dreifuss muscular dystrophy: a test case for precision medicine

The Application of Clinical Genetics, 2016
De-Ann M Pillers,1 Nicholas H Von Bergen21Division of Neonatology and Newborn Medicine, 2Division of Cardiology, Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USAAbstract: Emery–Dreifuss muscular dystrophy (EDMD) is ...
Pillers DAM, Von Bergen NH
doaj  

The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth

Frontiers in Oncology
BackgroundTriple-negative breast cancer (TNBC) is a sub-classification of breast carcinomas, which leads to poor survival outcomes for patients. TNBCs do not possess the hormone receptors that are frequently targeted as a therapeutic in other cancer ...
Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Mark N. Adams, Parastoo Shahrouzi, Kenneth J. O’Byrne, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson   +8 more
doaj   +1 more source

FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

Cell Reports
Summary: The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium, a hallmark of
Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar, Faruk Hossen, Sayanti Datta, Vigneshwaran Vellingiri, Jagdish Chandra Joshi, Peter T. Toth, Nityanand Srivastava, Stephen Lenzini, Guangjin Zhou, James Lee, Mukesh K. Jain, Jae-Won Shin, Dolly Mehta   +15 more
doaj   +1 more source

A Novel Emerin/Nesprin-3 Interaction Mediates Nuclear Size Changes Induced by Oncogenic KRAS in Pancreatic Cancer Cells. [PDF]

Mol Cell Biol
LaRue-Nolan KC, Flores LF, Vera RE, Sigafoos AN, Hilario Garcia L, Almada LL, Tader BR, Rodriguez-Quevedo MF, May DG, Marks DL, Roux KJ, Fernandez-Zapico ME.   +11 more
europepmc   +1 more source

Nuclear envelope proteins in cancer: revisiting the significance of LEM-domain proteins. [PDF]

Front Cell Dev Biol
Jobe A, Mirza S, Vijayan R.
europepmc   +1 more source

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. [PDF]

J Biol Chem
Odell J, Nedza K, Lammerding J.
europepmc   +1 more source