Results 81 to 90 of about 4,236 (177)

Sequence and structural alignments reveal insights into ANKLE2 evolution and function

Protein Science, Volume 35, Issue 6, June 2026.
Abstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Adam T. Fishburn, Cole J. Florio, Chase L. S. Skawinski, Sydney S. Becker, Ethan Holleman, Avery E. Robertson, Rees Sitchon, Frédéric Chédin, Priya S. Shah   +8 more
wiley   +1 more source

Characterization of the DNA binding property of emerin

Proceedings of the Japan Academy, Series B, 2001
Emerin is an inner nuclear membrane protein, which is the gene product responsible for X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). In this study we extracted emerin from mammalian cells and examined the DNA binding property by in vitro binding assay with double-strand DNA cellulose.
HASE, Asako, ARAHATA, Kiichi
openaire   +2 more sources

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane [PDF]

, 2007
The type II inner nuclear membrane protein emerin is a component of the LINC complex that connects the nuclear lamina to the actin cytoskeleton. In emerin-null or -deficient human dermal fibroblasts we find that the centrosome is detached from the ...
Hutchison, CJ, Salpingidou, Georgia, Smertenko, A, Andrei Smertenko, Hausmanowa-Petrucewicz, I, Georgia Salpingidou, Salpingidou, G, Hussey, Patrick J, Smertenko, Andrei, Hutchison, Chris J, Patrick J. Hussey, Hussey, PJ, Hausmanowa-Petrucewicz, Irena, Irena Hausmanowa-Petrucewicz, Chris J. Hutchison   +14 more
core   +1 more source

Distrofia muscular de Emery-Dreifuss: relato de caso Emery-Dreifuss muscular dystrophy: case report

Arquivos de Neuro-Psiquiatria, 2006
A distrofia muscular de Emery-Dreifuss é uma forma de distrofia muscular freqüentemente associada a contraturas articulares e defeitos de condução cardíaca, que pode ser causada pela deficiência da proteína emerina na membrana nuclear interna das fibras ...
Ana Lucila Moreira Carsten, Paulo José Lorenzoni, Rosana Herminia Scola, Lineu César Werneck   +3 more
doaj   +1 more source

Computational Characterization of the Role of LEM2/LaminA Interactions on the Stability of BAF‐Dimer Using Molecular Simulations

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1104-1114, May 2026.
ABSTRACT The effect of the presence of the BAF‐binding LEM‐domain and LaminA Ig‐fold on the stability of the BAF dimer was studied qualitatively using non‐equilibrium pull simulations and quantitatively through the calculation of the potential of mean force profile along BAF–BAF separation distance.
Aswin Vinod Muthachikavil, Alexander von Appen, Thomas D. Kühne   +2 more
wiley   +1 more source

Affinity Purification of Emerin-Associated Proteins

, 2013
(A) Immunoblot of HeLa nuclear lysate proteins (L), or proteins affinity-purified using either BSA beads or emerin beads (see Materials and Methods), probed with antibody against actin.
Amy K Kowalski (56692), James M Holaska (56691), Katherine L Wilson (56693)   +2 more
core   +1 more source

The Pathogenesis and Therapies of Striated Muscle Laminopathies

Frontiers in Physiology, 2018
Emery-Dreifuss muscular dystrophy (EDMD) is a genetic condition characterized by early contractures, skeletal muscle weakness, and cardiomyopathy. During the last 20 years, various genetic approaches led to the identification of causal genes of EDMD and ...
Astrid Brull, Blanca Morales Rodriguez, Blanca Morales Rodriguez, Gisèle Bonne, Antoine Muchir, Anne T. Bertrand   +5 more
doaj   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source