Results 81 to 90 of about 4,186 (177)
The Pathogenesis and Therapies of Striated Muscle Laminopathies
Frontiers in Physiology, 2018 Emery-Dreifuss muscular dystrophy (EDMD) is a genetic condition characterized by early contractures, skeletal muscle weakness, and cardiomyopathy. During the last 20 years, various genetic approaches led to the identification of causal genes of EDMD and ...
Astrid Brull +5 more
doaj +1 more source
The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions [PDF]
PeerJ, 2013 Loss of function mutations in the nuclear inner membrane protein, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). X-EDMD is characterized by contractures of major tendons, skeletal muscle weakening and wasting, and cardiac conduction ...
Michele A. Wozniak +3 more
doaj +2 more sources
Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials
Advanced Science, Volume 13, Issue 4, 19 January 2026.Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang +6 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 1, Page 193-206, January 2026.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Affinity Purification of Emerin-Associated Proteins
, 2013 (A) Immunoblot of HeLa nuclear lysate proteins (L), or proteins affinity-purified using either BSA beads or emerin beads (see Materials and Methods), probed with antibody against actin.
Amy K Kowalski (56692) +2 more
core +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen +23 more
wiley +1 more source
Experimental and Molecular MedicineMicronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive elements but could instead play active roles in ...
Marta Popęda +20 more
doaj +1 more source
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
Nature Communications, 2020 During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear.
Paulina Nastały +13 more
doaj +1 more source
The spatial relationship of human chromosomes within the nuclei of normal and emerin-mutant cells
, 2001 Mahy, N +5 more
core +6 more sources
eLife, 2019 The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
Abigail Buchwalter +4 more
doaj +1 more source