Results 101 to 110 of about 4,236 (177)

Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

eLife, 2019
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
Abigail Buchwalter, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, Martin Hetzer   +4 more
doaj   +1 more source

Emerin Binds the Pointed End of Actin Filaments

, 2013
(A) Gelsolin–actin seeds were incubated with increasing concentrations of wild-type emerin residues 1–222. Emerin significantly reduced the rate of subunit addition at the pointed end, with an apparent Kd of 430 nM (range, 300–500 nM, n = 12). R, rate of
Amy K Kowalski (56692), James M Holaska (56691), Katherine L Wilson (56693)   +2 more
core   +1 more source

Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. [PDF]

, 2016
Emerin is a tail-anchored protein that is found predominantly at the inner nuclear membrane (INM), where it associates with components of the nuclear lamina.
Vilardi, F., Monroy, Jhon Rivera, Kehlenbach, Ralph H., Jamieson, Cara, Vilardi, Fabio, Pfaff, J., Schwappach, B., Schwappach, Blanche, Jamieson, C., Monroy, J., Kehlenbach, R., Pfaff, Janine, Rajanala, Kalpana, Rajanala, K.   +13 more
core   +1 more source

Developmental changes in nuclear lamina components during germ cell differentiation

Nucleus
The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell differentiation.
Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer   +3 more
doaj   +1 more source

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies

European Journal of Histochemistry, 2009
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi, G Lattanzi, C Capanni, M Columbaro, L Merlini, E Mattioli, P Sabatelli   +6 more
doaj   +1 more source

IMPACT OF BETA‐DYSTROGLYCAN DEFICIENCY ON EMERIN FUNCTIONS

The FASEB Journal, 2018
Beta‐dystroglycan (b‐DG) is a plasma membrane protein that belongs to the dystrophin‐associated protein complex (DAPC), the latter provides a link between the extracellular matrix and the cytoskeleton. Previously we reported that b‐DG is translocated localized to the nucleus via recognition of its nuclear localization signal (NLS), located in the ...
Jesús Mauricio Ernesto Hernández Méndez, Wendy Lilián Gómez Monsiváis, Ricardo Mondragón González, Rita Perlingeiro, Jaime García Mena, Bulmaro Cisneros Vega   +5 more
openaire   +1 more source

The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype

, 2002
Emerin is the nuclear membrane protein defective in X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). The majority of X-EDMD patients have no detectable emerin.
Kendrick-Jones, J, Riddell, A, Fairley, E A, Ellis, J A   +3 more
core   +3 more sources

The inner nuclear membrane protein Emerin regulates beta-cateninactivity by restricting its accumulation in the nucleus

Emerin is a type II inner nuclear membrane (INM) protein of unknown function. Emerin function is likely to be important because, when it is mutated, emerin promotes both skeletal muscle and heart defects.
Blankesteijn WM, Salpingidou G, Tilgner K, Ramaekers FCS, Markiewicz E, Clevers H, Ellis JA, Barker N, Broers JLV, Wilson RG, Dorobek M, Hausmanowa-Petrusewicz I, Hutchison CJ, van de Wetering M   +13 more
core   +3 more sources

The Role of Emerin in Myogenic Differentiation

The nucleus harbors genetic material encapsulated by the nuclear envelope which is composed of an inner and outer nuclear membrane. The establishment and organization of chromatin at the INM is essential for cell fate during the differentiation program ...
Marano, Nicholas
core   +1 more source

An Intronic Heterozygous SYNE2 Splice Site Mutation: A Rare Cause for Myalgia and hyperCKemia?

Muscles
SYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-exome
Theresa Paulus, Natalie Young, Emily Jessop, Carolin Berwanger, Christoph Stephan Clemen, Rolf Schröder, Rafal Ploski, Christian Hagel, Yorck Hellenbroich, Andreas Moser, Iakowos Karakesisoglou   +10 more
doaj   +1 more source