Results 101 to 110 of about 6,334 (202)

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, Volume 24, Issue 10, October 2025.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

eLife, 2019
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
Abigail Buchwalter, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, Martin Hetzer   +4 more
doaj   +1 more source

Alterations to nuclear architecture and genome behavior in senescent cells. [PDF]

, 2007
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions.
Abney J.R., Agrelo R., Barboro P., Becker P.B., Bemiller P.M., Benn P.A., Berezney R., Bowman P.D., Bridger J.M., Bridger J.M., C. S. CLEMENTS, Campisi J., Chaly N., Chang K.S., Cremer T., de Lange T., Dell'Orco R.T., Dijkwel P.A., Ferbeyre G., Filesi I., Fisher A.G., Fleischer S., Goldman R.D., Gruenbaum Y., Haque F., Hernandez-Verdun D., Holliday R., Hozak P., I. R. KILL, I. S. MEHTA, J. M. BRIDGER, Kill I.R., Kreth G., Lezhava T., Li Y., M. FIGGITT, Mallette F.A., Manuelidis L., Mazin A.L., Mitsui Y., Mukherjee A.B., Nickerson J., Okabe J., Padiath Q.S., Pawelec G., Petrova N.V., Schardin M., Schulz L., Smilenov L.B., Strouboulis J., Tanabe H., van Driel R., Wang G.S.   +52 more
core   +1 more source

Developmental changes in nuclear lamina components during germ cell differentiation

Nucleus
The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell differentiation.
Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer   +3 more
doaj   +1 more source

Integrating hierarchical controlled vocabularies with OWL ontology: A case study from the domain of molecular interactions [PDF]

, 2007
Many efforts at standardising terminologies within the biological domain have resulted in the construction of hierarchical controlled vocabularies that capture domain knowledge. Vocabularies, such as the PSI-MI vocabulary, capture both deep and extensive
Davis, M., Hunter, J., Khan, I., Newman, A., Ragan, M. A.   +4 more
core   +1 more source

Ancient eukaryotic origin and evolutionary plasticity of nuclear lamina [PDF]

, 2016
The emergence of the nucleus was a major event of eukaryogenesis. How the nuclear envelope (NE) arose and acquired functions governing chromatin organization and epigenetic control has direct bearing on origins of developmental/stage-specific expression ...
Field, Mark C., Koreny, Ludek
core   +2 more sources

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies

European Journal of Histochemistry, 2009
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi, G Lattanzi, C Capanni, M Columbaro, L Merlini, E Mattioli, P Sabatelli   +6 more
doaj   +1 more source

Characterization of the DNA binding property of emerin

Proceedings of the Japan Academy, Series B, 2001
Emerin is an inner nuclear membrane protein, which is the gene product responsible for X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). In this study we extracted emerin from mammalian cells and examined the DNA binding property by in vitro binding assay with double-strand DNA cellulose.
Asako HASE, Kiichi ARAHATA
openaire   +2 more sources

IMPACT OF BETA‐DYSTROGLYCAN DEFICIENCY ON EMERIN FUNCTIONS

The FASEB Journal, 2018
Beta‐dystroglycan (b‐DG) is a plasma membrane protein that belongs to the dystrophin‐associated protein complex (DAPC), the latter provides a link between the extracellular matrix and the cytoskeleton. Previously we reported that b‐DG is translocated localized to the nucleus via recognition of its nuclear localization signal (NLS), located in the ...
Jesús Mauricio Ernesto Hernández Méndez, Wendy Lilián Gómez Monsiváis, Ricardo Mondragón González, Rita Perlingeiro, Jaime García Mena, Bulmaro Cisneros Vega   +5 more
openaire   +1 more source

Serum cystatin C and chemerin levels in diabetic retinopathy [PDF]

, 2017
Peer reviewedPublisher ...
Chen, Xuedong, Li, Qingjun, Yu, Tian, Yu, Yongbin, Zhang, Liqiong, Zhao, Shiyong   +5 more
core