Results 101 to 110 of about 13,374 (270)
Chemistry &Biodiversity, Volume 22, Issue 1, January 2025.Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Nadine Henning +5 more
wiley +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2004 Background Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment, yet the susceptibility data on clinical isolates of Entamoeba histolytica and Entamoeba ...
Mahajan Ramesh +4 more
doaj +1 more source
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
BioMed Research International, Volume 2025, Issue 1, 2025.Antimicrobial multidrug resistance is the ability of microorganisms to withstand the effects of several antimicrobial agents, presenting a major challenge to modern healthcare systems worldwide. Although considerable research has been conducted, the molecular and evolutionary mechanisms underlying resistance are still not completely understood.
Abraham Belete Temesgen +2 more
wiley +1 more source
Selenite Targets eIF4E-Binding Protein-1 to Inhibit Translation Initiation and Induce the Assembly of Non-Canonical Stress Granules [PDF]
, 2012 Stress granules (SGs) are large cytoplasmic ribonucleoprotein complexes that are assembled when cells are exposed to stress. SGs promote the survival of stressed cells by contributing to the reprogramming of protein expression as well as by blocking pro ...
Anderson, Paul Joseph +2 more
core +1 more source
Human Mutation, Volume 2025, Issue 1, 2025.COL4A5 gene variants could result in the X‐linked Alport syndrome 1, dominant inheritance (XLAS1) (Online Mendelian Inheritance in Man (OMIM) #301050). The splicing changes can be identified through targeted RNA sequencing (RNA seq), but obtaining accessible patient samples from urine cells and skin fibroblasts is challenging.
Yixiao Li +13 more
wiley +1 more source
Analysis of Mitochondrial Protein Synthesis: De Novo Translation, Steady-State Levels, and Assembled OXPHOS Complexes. [PDF]
, 2018 Mitochondria are multifunctional organelles with their own genome and protein synthesis machinery. The 13 proteins encoded by mitochondrial DNA (mtDNA) are core subunits of the oxidative phosphorylation (OXPHOS) system producing the majority of cellular ...
D'Amico +9 more
core +1 more source
The FEBS Journal, Volume 291, Issue 24, Page 5506-5522, December 2024.The mitochondrial disulphide relay machinery is essential for the import and oxidative folding of many proteins in the mitochondrial intermembrane space. MIA40 is a core component of this machinery, and after non‐covalent interaction, it introduces disulphide bonds into its substrates.
Robin Alexander Rothemann +11 more
wiley +1 more source
Activation of p34cdc2 kinase by cyclin A [PDF]
, 1991 Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Both cyclin A and B can induce meiosis I and meiosis II in Xenopus in the absence of protein synthesis.
Gabrielli, B. G. +6 more
core +1 more source
The Trans Golgi Region is a Labile Intracellular Ca2+ Store Sensitive to Emetine
Scientific Reports, 2018 The Golgi apparatus (GA) is a bona fide Ca2+ store; however, there is a lack of GA-specific Ca2+ mobilizing agents. Here, we report that emetine specifically releases Ca2+ from GA in HeLa and HL-1 atrial myocytes. Additionally, it has become evident that
M. Gallegos-Gomez +5 more
semanticscholar +1 more source
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signalling [PDF]
, 2014 Dysfunctional regulation of signalling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes.
Charron, Maureen J. +11 more
core +1 more source