Results 91 to 100 of about 231,498 (381)

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT

open access: yesEuropean Radiology Experimental
Background Emphysema influences the appearance of lung tissue in computed tomography (CT). We evaluated whether this affects lung nodule detection by artificial intelligence (AI) and human readers (HR).
Nikos Sourlos   +10 more
doaj   +1 more source

Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction [PDF]

open access: yes, 2017
Background: The degree of interlobar emphysema heterogeneity is thought to play an important role in the outcome of endoscopic lung volume reduction (ELVR) therapy of patients with advanced COPD.
Doellinger, Felix   +5 more
core   +1 more source

Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is a genetic disease, α-1 antitrypsin (AAT) deficiency.
F. Borel   +13 more
semanticscholar   +1 more source

Is Ophthalmology Consult Needed for Acute Orbital Fractures?

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Failure to recognize concomitant ocular injury in orbital fracture patients is a feared consequence of evaluation in the acute setting. These injuries and their accompanying functional sequelae range in severity, and reconstructive surgeons need to be sensitive to the possibility of major ocular injuries that could potentially have serious ...
Katherine L. Webb   +2 more
wiley   +1 more source

A Case of Parapharyngeal Emphysema due to Temporal Bone Fracture as a Sequel of Traumatic Road Accident. [PDF]

open access: yesClin Case Rep
ABSTRACT We report the case of a 45‐year‐old male who presented to the emergency department with otorrhagia following a road traffic accident. Initial examination showed no neurological deficits, and computed tomography (CT) imaging revealed a subtle right temporal bone fracture with associated parapharyngeal emphysema.
Ishaq MU   +4 more
europepmc   +2 more sources

Postoperative Fluoroscopic Appearance After Flexible Endoscopic Zenker's Diverticulotomy

open access: yesThe Laryngoscope, EarlyView.
We perform a retrospective study on patients undergoing flexible Zenker's diverticulotomy surgery and report changes in the objective fluoroscopic appearance as well as patient‐reported outcome measures. ABSTRACT Objective Flexible approach to treating Zenker's diverticulum (ZD) has gained traction in recent years. However, objective measures comparing
Shumon I. Dhar   +7 more
wiley   +1 more source

Alpha-1 antitrypsin deficiency [PDF]

open access: yes, 2001
α-1 antitrypsin is synthesised in the liver and protects lung alveolar tissues from destruction by neutrophil elastase. α-1 antitrypsin deficiency is a common autosomal recessive condition (1:1600 to 1:1800) in which liver disease results from retention ...
Primhak, R.A., Tanner, M.S.
core   +2 more sources

Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort.

open access: yesRadiology, 2018
Purpose To determine if interstitial features at chest CT enhance the effect of emphysema on clinical disease severity in smokers without clinical pulmonary fibrosis. Materials and Methods In this retrospective cohort study, an objective CT analysis tool
S. Ash   +19 more
semanticscholar   +1 more source

Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction

open access: yesERJ Open Research, 2021
Sandra Rutting   +7 more
doaj   +1 more source

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