Results 31 to 40 of about 188,190 (286)
Quantitative CT analysis in patients with pulmonary emphysema: is lung function influenced by concomitant unspecific pulmonary fibrosis? [PDF]
, 2019 Purpose: Quantitative analysis of CT scans has proven to be a reproducible technique, which might help to understand the pathophysiology of chronic obstructive pulmonary disease (COPD) and combined pulmonary fibrosis and emphysema.
Doellinger, Felix +5 more
core +1 more source
Clinical and Translational Medicine, 2022 Background Programmed death‐ligand 1 (PD‐L1) has functional roles in cancer stem‐like cell (CSC) phenotypes and chemoresistance besides immune evasion.
Hye‐Young Min +14 more
doaj +1 more source
, 2004 The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1.
Ashida, Kozo +7 more
core +1 more source
Nature Communications, 2016 The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling.
Hye-Jin Boo +14 more
doaj +1 more source
Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. [PDF]
PLoS ONE, 2016 To differentiate smoking-related interstitial fibrosis (SRIF) from usual interstitial pneumonia (UIP) with emphysema on CT in combined pulmonary fibrosis and emphysema (CPFE) patients.This study was approved by the institutional review board and informed
Kum Ju Chae +7 more
doaj +1 more source
New Spirometry Indices for Detecting Mild Airflow Obstruction. [PDF]
, 2018 The diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstration of airflow obstruction. Traditional spirometric indices miss a number of subjects with respiratory symptoms or structural lung disease on imaging.
Barjaktarevic, Igor +13 more
core +2 more sources
Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development [PDF]
, 2018 Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma.
Fisher, Amanda J. +8 more
core +1 more source
Attitudes and access to lung volume reduction surgery for COPD: a survey by the British Thoracic Society. [PDF]
, 2014 OBJECTIVE: Lung volume reduction surgery for emphysema leads to improved survival in appropriately selected individuals, and it is therefore recommended in national and international guidelines for this group of patients.
Hopkinson, NS, Jordan, S, McNulty, W
core +1 more source
Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity
Angewandte Chemie, EarlyView.A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu +16 more
wiley +2 more sources
Frontiers in Medicine, 2021 Objective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD).Methods/Design: Patients ...
Plácido Gomes +15 more
doaj +1 more source