Results 31 to 40 of about 218,651 (379)
New England Journal of Medicine, 2003 BACKGROUND Lung-volume-reduction surgery has been proposed as a palliative treatment for severe emphysema. Effects on mortality, the magnitude and durability of benefits, and criteria for the selection of patients have not been established.
A. Fishman +7 more
semanticscholar +1 more source
Molecular Cancer, 2018 Background Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting
Ho Jin Lee +8 more
doaj +1 more source
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]
, 2011 Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong +4 more
core +1 more source
American Journal of Physiology - Cell Physiology, 2018 Cigarette-smoke (CS) exposure and aging are the leading causes of chronic obstructive pulmonary disease (COPD)-emphysema development, although the molecular mechanism that mediates disease pathogenesis remains poorly understood.
N. Vij +4 more
semanticscholar +1 more source
A circadian based inflammatory response – implications for respiratory disease and treatment
Sleep Science and Practice, 2017 Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and ...
Maria Comas +8 more
doaj +1 more source
Association between plasma sRAGE and emphysema according to the genotypes of AGER gene
BMC Pulmonary Medicine, 2022 Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin +4 more
doaj +1 more source
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]
, 2019 We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor +10 more
core +1 more source
Basilar Predominant Emphysema: Thinking beyond Alpha-1-Antitrypsin Deficiency
Case Reports in Medicine, 2022 Basilar predominant emphysema, or disproportionate emphysematous involvement of the lung bases compared to the apices, is an uncommon radiographic pattern of emphysema traditionally associated with alpha-1-antitrypsin deficiency (AATD). We present a case
Ho-Man Yeung, Lauren Gaffaney
doaj +1 more source
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core +2 more sources