Results 81 to 90 of about 694,998 (286)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Digitalization of Employee Performance Appraisal System: Ensuring Fairness and Transparency in Human Resource (HR) Practices in Steel Construction Company

Journal the Winners
Digital transformation in human resource department (HRD) within performance appraisal process is initiated from employee management and supported by the commitment of leaders to create aspects of openness and fairness. In this context, PT.
Alexander Wirapraja, Rizky Basatha, Fanny Megawati Manggaetan   +2 more
doaj  

The Implementation of Appraisal Information System to Enhance Education Personnel Performance: Evidence from Universitas Negeri Malang

JPBM (Jurnal Pendidikan Bisnis dan Manajemen), 2021
This study aims at explaining the relationship between work performance appraisal information systems, work performance appraisals and the performance of education personnel.
Fitria Puji Harmini, Abdul Hakim, Ike Wanusmawatie   +2 more
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Exploring the mediating role of appraisal fairness between the relationship of ethical behaviour and employee performance: moderating role of organisational culture

Discover Sustainability
Employee performance remains a critical concern for organisations, particularly when undermined by unethical behaviour and unsupportive cultural environments.
Musa Muhammad, Mohammad Abdullah Al Mamun, Md Ashraf Ali, Md. Mamun Hossain, Naima Khan Tarin, Balayet Hossain, Rehnuma Mostafa, Hasan Ahmed   +7 more
doaj   +1 more source

PERFORMANCE APPRAISAL OF EMPLOYEES

Performance appraisal helps to measure the strengths and weaknesses of employees. Theperception of employees towards performance appraisal systems had been described in thispaper. It is observed from this study that performance motivates employees and it providesfeedback on their capabilities.
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Study on Employee Performances Appraisal

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
ABSTRACT: Performance appraisals are essential tools in the workplace, helping to uncover skill gaps, identify areas where training is needed, and foster the professional growth of employees. By using well-designed surveys, organizations can better understand how employees perceive the appraisal process and how effective it is.
openaire   +1 more source