Results 61 to 70 of about 1,043,884 (276)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Developing a Plan to Decrease Employee Turnover Intention by Focusing on the Impact of Organizational Culture and Work Environment, Using Job Satisfaction as a Mediator

Manazhim
The objective of this study is to analyse the factors that impact employee performance, namely the effect of remuneration and punishment, with satisfaction acting as a mediating factor.
Satria Pinandita, Djoko Soelistya, Eva Desembrianita   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Effect of Discipline on Employee Performance

IJESS International Journal of Education and Social Science
This study aims to determine the effect of discipline on employee performance at PT. Pasti Jaya Tehnik Tangerang. The population in this study consisted of employees of PT. Pasti Jaya Tehnik Tangerang. The sample used was 30 employees of PT. Pasti Jaya Tehnik Tangerang. This research is quantitative in nature.
Yhonanda Harsono, null Turmuzi, Indah Pertiwi   +2 more
openaire   +1 more source

The Influence of Discipline and Competency Toward Employee's Performance

SSRN Electronic Journal, 2015
The purpose of this study was to analyze and determine the Influence of Discipline and Competency toward Employee’s Performance The population of this study was 145 Employees of Department of Public Works Office especially those in the Division of Highways.
Nurwati Nurwati, Alida Palilati, Rahmat Madjid, Nasrul Nasrul   +3 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Effect of Motivation and Work Discipline on Employee Performance

Almana: Jurnal Manajemen dan Bisnis, 2020
Human resources have a major role in every organizational activity for the achievement of company goals. Employee performance levels need to be considered to achieve high productivity.
Winda Nurmayanti, Enang Narlan SAP
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source