Results 81 to 90 of about 1,043,884 (276)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The impact additional of employee income and work discipline on employee performance: An empirical study at the Gorontalo Regency Social Service Agency

Journal of Management Small and Medium Enterprises (SME's)
This study aims to analyze the effect of Additional Employee Income (TPP) and Work Discipline on Employee Performance at the Gorontalo Regency Social Service. The background of this study stems from the phenomenon of declining volume and quality of work
Sri Safrilla H Z Rivai, Heldy Vanni Alam, Melan Angriani Asnawi   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

PENGARUH KEPEMIMPINAN, KEDISIPLINAN DAN MOTIVASI KERJA TERHADAP PRODUKTIVITAS MELALUI KINERJA KARYAWAN (Studi Empiris Pada Perusahaan Daerah Perkebunan (PDP) Kabupaten Jember)

Jurnal Ekonomi Akuntansi dan Manajemen, 2015
Halil1, Bagus P. Yudhia K.2, Tanti Kustiari2 1 Mahasiswa Program Studi Agribisnis Program Pascasarjana Magister Terapan Politeknik Negeri Jember. 2 Dosen Pascasarjana Magister Terapan Politeknik Negeri Jember. Alamat: Jl. Mastrip, Jawa Timur 68101,
Halil Halil, Bagus P. Yudhia K, Tanti Kustiari   +2 more
doaj  

PENGARUH KEPEMIMPINAN DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PADA PT CENTRAL CAPITAL FUTURES CABANG MALANG

Jurnal Ilmiah Bisnis dan Ekonomi Asia, 2018
This study aims to determine: (1). The influence of leadership on employee performance of PT Central Capital Futures Malang Branch; (2). The influence of work discipline on employee performance of PT Central Capital Futures Malang Branch; (3).
Any Isvandiari, Bagus Al Idris
doaj   +1 more source

Efficiency Wage and Labor Discipline Models: Matched-Panel Evidence from Brazilian Construction Industry [PDF]

The aim of this paper is to test the relationship between wage and workers’ labor effort for the Brazilian construction industry. This relationship is stated by both the shirking and the labor discipline versions of efficiency wage models.
Luiz A. Esteves
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source