Results 71 to 80 of about 9,658 (260)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Multiculturalism in the workplace: Model and test

SA Journal of Human Resource Management, 2018
Orientation: This article addresses the role of multiculturalism in employee attitudes. Research purpose: It proposes a model of positive features of multiculturalism in organisations and tests it in South Africa.
Leon T.B. Jackson, Fons J.R. van de Vijver   +1 more
doaj   +1 more source

Integrating Employee Benefits and Competitive Strategy

Journal of Business Strategies, 1970
As the costs of employee benefits have escalated, labor cost control to enhance product market competitiveness has become a more critical organizational concern. However, benefits which are an element of compensation have remained a relatively neglected topic in the area of strategic human resource management.
Margaret Lucero, Marion White
openaire   +2 more sources

An analysis of the direct and mediated effects of employee commitment and supply chain integration on organisational performance [PDF]

, 2014
This paper focuses on the interrelationships among the different dimensions of supply chain integration. Specifically, it examines the relationship between employee commitment and supply chain integration dimensions to explain several performance ...
Alfalla Luque, Rafaela, Medina-Lopez, Carmen, Marin-Garcia, Juan A., Alfalla-Luque, Rafaela, Medina López, Carmen, Marín García, Juan Antonio   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

How technological innovation and organizational culture influence circular economy adoption over time in Saudi Arabian manufacturing

Discover Sustainability
This study explores the factors influencing circular economy adoption, a critical endeavor to achieve sustainability and environmental goals. Our study focuses on 222 people in executive and sustainability officer positions in different parts of the ...
Naima Sadaoui, Houcine Benlaria, Naeimah Fahad Almawishir, Balsam Saeed Abdelrhman, Sumaya Awad Khader Ahmed, Lotfi Zabat, Badreldin Mohamed Ahmed Abdulrahman, Rania Alaa Eldin Ahmed Khedr   +7 more
doaj   +1 more source

METHODS OF RESOLVING CONFLICT IN AN ENTERPRISE AND EMPLOYEES INTEGRATION

Ekonomia i Prawo, 2012
This article aims to show the relationship between the method of resolving conflicts in the company and employees integration. Selection methods of conflict resolution has a significant impact on employee integration process. Choosing traditional methods of conflict resolution must reckon with the fact that their consequence is the disintegration of ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Employee Innovation Process: An Integrative Model

Journal of Innovation Management, 2019
Enormous research has focused on investigating innovation process in organisations but only a few are devoted to employee innovation process, thus limiting our understanding of how to organise, foster and successfully manage employee innovation process in organisation.
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source