Results 51 to 60 of about 961,905 (214)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2003 Annual; Dec. 31, 2002-; Description based on: 2002; title from PDF cover (viewed on Jan.
Ohio Public Employees Retirement System.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New Employees Benefit Guide: Plan Year 2013
, 2012 This is a new employees benefit and retirement plan guide for employees of the state of Texas for ...
Employees Retirement System of Texas
core
Your ERS Connection: Discussing Retiree Benefits and Other News [PDF]
, 2021 Newsletter of the Employees Retirement System of Texas discussing news, policy changes, and other information about retirement and ...
Employees Retirement System of Texas
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Los Angeles County Employees Bulletin, Vol. 5 No. 5, May 1927
, 2016 Los Angeles County Employees Bulletin, Vol. 5 No.
Los Angeles County Employees Association
core
JPH RECODE (Journal of Public Health Research and Community Health Development)Background: Single Male Migrants (SMMs) are highly vulnerable and at high risk of acquiring and spreading sexually transmitted infections (STIs) due to a lack of social support networks, unstable legal status, cultural and language barriers, high ...
M Shashi Kumar +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source