Results 61 to 70 of about 4,700 (233)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Does employer brand fuel job satisfaction? The role of intrinsic motivation
BizInfoThe employer brand strategically positions companies as attractive workplaces to secure and retain top talent. Elements within the reward system, known as dimensions of the employer brand, are crafted to create unique working conditions fostering job ...
Goran Pavlović, Marko Slavković
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2017 W dobie zmieniającego się świata coraz większą uwagę przywiązuje się do wizerunku przedsiębiorstwa. To, aby był on postrzegany, jako silny i pozytywny zależy w głównej mierze od tego, jakie działania podejmuje firma. Obecnie nie wystarczy działać i dopasowywać się do rynku.
openaire +3 more sources
SA Journal of Human Resource Management, 2020 Orientation: Companies leverage employer, internal and corporate brand building practices as they compete to attract and retain the rare talent required for organisational success. Research purpose: To explore, in the context of global leading practice,
Michelle B. Wolfswinkel, Carla Enslin
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Thought about Human Side of Brand: Considering the Effect of Employer Brand on Human Capital Satisfaction [PDF]
بهبود مدیریت, 2015 In competitive labor markets, the challenge for organizations is to differentiate themselves in order to successfully attract and retain the best staff. Building distinctive employer brand can help an organization gain competitive advantage by attracting
Tahmores Hasangholipor +3 more
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