Results 81 to 90 of about 1,592,470 (309)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Would you train me with my mental illness? Evidence from a discrete choice experiment [PDF]

open access: yes
The low employment among people with disabilities in general, and mental disorders in particular, generates high costs to the society. This raises the need to develop effective vocational rehabilitation methods.
Deuchert, Eva   +2 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

A randomized controlled trial protocol for evaluating the feasibility, acceptability, and work outcomes of individualized placement and support adapted for autistic adults in the community

open access: yesContemporary Clinical Trials Communications
Relatively few autistic adults, including those with average intellectual abilities, are competitively employed, meaning that they hold jobs together with non-disabled workers and receive comparable wages and benefits.
Marjorie Solomon   +6 more
doaj   +1 more source

International employment schemes for people with mental health problems

open access: yesBJPsych International, 2015
It has been recognised that work is a positive factor for mental health since the days of Galen (2nd century CE). It was central to the theories and practice of William Tuke at the Retreat in York (founded 1796) and has continued in different forms as a ...
Bob Grove
doaj   +1 more source

The social & economic implications of alternative land uses involving pastoral farming and forestry in Northland : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Natural Resource and Environmental Economics at Massey University [PDF]

open access: yes, 1987
This thesis is a scenario study which examines the social and economic impacts of different types of forestry being established in an area of pastoral farmland in Northland, New Zealand.
Smith, David Hardie
core  

Service users' perceptions of the effective ingredients in supported employment [PDF]

open access: yes, 2009
Background: The UK government is advocating the use of supported employment to help people on incapacity benefits back to work, with an emphasis on Individual Placement and Support (IPS) models.
Becker D.   +18 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Supported employment among veterans with serious mental illness: the role of cognition and social cognition on work outcome

open access: yesSchizophrenia Research: Cognition, 2014
Unemployment is a primary functional deficit for the majority of adults with schizophrenia. Research indicates that over two-thirds of adults living in the community with schizophrenia are unemployed.
L. Felice Reddy, Robert S. Kern
doaj   +1 more source

The motivation to migrate, acculturation, and finding employment : the case of African migrants in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of a Master of Arts in Psychology at Massey University [PDF]

open access: yes, 2008
The present study tested a model whereby Psychological Acculturation mediated the relationship between the Psychological Motives to Migrate and the Employment Outcome of African migrants in New Zealand.
Udahemuka, Martine Marie-Gloria
core  

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