Results 111 to 120 of about 10,463,905 (347)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

The ‘network economy’ and models of the employment contract. [PDF]

open access: yes
The development of the ‘network economy’ and project-based work challenge established methods of regulating employment relationships. There appears to be an unsatisfied demand for its greater use, especially among employers, and this may be blocked by ...
Marsden, David
core   +1 more source

Forecasting the Labor Market Prospects of Low-Skilled Americans [PDF]

open access: yes, 2005
This paper forecasts the post-recession labor market experiences of less-skilled men and women. It uses empirical relationships and the Bush Administration's 2004 and 2005 forecasts of the national unemployment rate to predict the employment-population ...
William M. Rodgers
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Terminating an Employment Contract at the Employer’s Will: Does Expensive and Simple Mean Safe? Lithuanian Model

open access: yesBaltic Journal of Law & Politics
This paper aims to reveal the nature, specifics and limits of application of one of the legal grounds for termination of employment relationships established in the labour law of the Republic of Lithu ania – termination of the employment contract at the ...
Bartninkas Marius
doaj   +1 more source

The Employment Contract as a Central Institute of Labour Law – Past vs. Present [PDF]

open access: yesSocietas et Iurisprudentia, 2015
The freedom of contracts forms the basis of the private-law aspects of the labour law and, in the same time, it expresses a part of the parties’ freedom in the form of contractual autonomy.
Miriam Laclavíková, Andrea Olšovská
doaj  

Diversity of employment contracts and use of the law [PDF]

open access: yes
From the construction of a French data base of 309 employment contracts, we analyse current practices in firms, their manpower management methods and their use of the law in the drafting of employment contracts.
Christian Bessy
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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