Results 91 to 100 of about 10,463,905 (347)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An incomplete double movement: Spain’s legislative strategy for platform courier reclassification
International Labour ReviewDigital labour platforms, which have long operated outside conventional employment frameworks, are now facing a regulatory drive. Spain seems to be at the forefront of this international effort, notably through a set of legislative initiatives – most ...
Tiago Alexandre VIEIRA
doaj +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
ANALYSES OF THE RELATIONSHIP BETWEEN EXCHANGE RATES AND EMPLOYMENT IN KOREA [PDF]
Previous studies about relationship between exchange rates and employment focus on only developed countries. But country characteristics in developing countries are different from those of developed countries.
Wanjoong Kim
core
Anglo-American corporate governance and the employment relationship: a case to answer [PDF]
, 2005 The corporate governance environment in the UK and US is generally thought to be hostile to the emergence of cooperative employment relations of the kind exemplified by labour-management partnerships.
Deakin, S. +3 more
core +1 more source
Psychological contract breach during the pandemic: How an abrupt transition to a work from home schedule impacted the employment relationship. [PDF]
J Bus Res, 2023 Gong B, Sims RL.
europepmc +1 more source
Community Rehabilitation Programs and Organizational Change: A Mentor Guide to Increase Customized Employment Outcomes [PDF]
, 2007 [Excerpt] For the purpose of this Guide, customized employment is defined as a process for individualizing the employment relationship between an employee and an employer in ways that meet the needs of both.
Butterworth, John +3 more
core +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
MINIMUM WAGE – THE RULE INSTEAD OF THE EXCEPTION IN THE LABOR MARKET
PravoThe issue of the minimum wage has been attracting attention for many years, not only from experts, but also from the general public. Determining the minimum wage in every country, including Serbia, aims to establish minimum standards for personal income
Vladimir Radovanović +1 more
doaj +1 more source